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Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers.
TLDR
It is concluded that drug dissolved in the coarse lipid particles formed after administration of a triglyceride solution can directly contribute to the flux of lipophilic drugs across the intestinal mucosa.
Chewability testing in the development of a chewable tablet for hyperphosphatemia
TLDR
The developed tests are shown to be more suitable for evaluating chewing properties of tablets than currently used Pharmacopeial tests and enabled the optimal chewability features of PA21 tablets in development to be confirmed whilst still maintaining capabilities for robust production and transportation processes.
Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness.
TLDR
Development and characterized transport media that simulate the composition of micellar phase of intestinal fluids in the fasted and in the fed state and are appropriate for evaluating intestinal drug permeability characteristics using the Caco-2 model and the impact of reduced P value on flux through the mucosa needs to be taken into consideration in PBPK modeling.
Effect of Concentration and Degree of Saturation of Topical Fluocinonide Formulations on In Vitro Membrane Transport and In Vivo Availability on Human Skin
TLDR
It can be concluded, that the drug flux might be increased supra-proportionally with increasing donor concentration, drug (super-)saturation (proportional), beyond what would be anticipated based on ideal donor concentration and partition coefficient considerations only.
Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro.
TLDR
It can not be concluded whether the concentration of LMWH achieved at the blood capillaries is sufficient to exert a pharmacological effect, but molecular weight and liposomal formulations influenced the penetration pattern of Heparin in the epidermis.
In Vitro and Ex Vivo Investigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA
TLDR
Using PAMPA, the impact of luminal micellar phase on passive permeability of lipophilic molecules varies with the molecule, and permeability with furosemide and Compound B steadily decreased in the presence of increasing micelle concentration of media.
Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model.
TLDR
Liposomal solubilization considerably increased drug concentration in the media and altered absorption behavior by affecting both the passive diffusion and the carrier mediated efflux components of cell monolayer permeation.
Advancing in‐vitro drug precipitation testing: new process monitoring tools and a kinetic nucleation and growth model
TLDR
New analytical tools and a kinetic nucleation and growth model were introduced to in‐vitro drug precipitation testing in biorelevant media for poorly soluble weak bases during intestinal passage, potentially leading to incomplete drug absorption.
Pharmacokinetics and pharmacodynamics of nasally delivered midazolam.
TLDR
Effective midazolam serum concentrations were reached within less than 10 min after nasal application of a highly concentrated midazlam formulation containing an equimolar amount of the solubilizer RMbetaCD combined with the absorption enhancer chitosan.
Different modes of dynamic image analysis in monitoring of pharmaceutical dry milling process.
TLDR
The concept of TESSA was found to be useful in detecting changes in milling conditions including the successful detection of a damaged screen when intentionally introduced in the milling process.
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