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  • Howard A. Rockman, Kenneth R Chien, +5 authors Walter J. Koch
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 9 June 1998)
  • Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. An importantExpand
  • L. D'Andrea, G. Iaccarino, +5 authors C. Pedone
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 4 October 2005)
  • Modulating angiogenesis is an attractive goal because many pathological conditions depend on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a mitogen specific forExpand
  • D. Sorriento, M. Ciccarelli, +9 authors G. Iaccarino
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 18 November 2008)
  • G-protein-coupled receptor (GPCR) kinases, GRKs, are known as serine/threonine kinases that regulate GPCR signaling, but recent findings propose functions for these kinases besides receptorExpand