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The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
TLDR
The complete sequence of the GC-rich genome of Methanopyrus kandleri is determined by using a whole direct genome sequencing approach and indicates that archaeal methanogens are monophyletic.
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
TLDR
Wip1 is an important mammalian phosphatase for gamma-H2AX and shows an additional mechanism for Wip1 in the tumor surveillance network, which is shown to disrupts recruitment of important DNA repair factors to damaged sites and delays DNA damage repair.
The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
TLDR
It is shown that resting T cells but not B cells from Gadd45a−/− mice had spontaneously increased p38 activity in the absence of 'upstream' MAPK kinase activation, which results in p38 activation, T cell hyperproliferation and autoimmunity.
Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis
TLDR
A group of Wip1 inhibitors with anticancer properties both in vitro and in vivo is reported, and it is proposed that these agents may serve as lead compounds for the development of anticancer drugs targeting Wip 1 phosphatase.
The Domain Organization and Properties of Individual Domains of DNA Topoisomerase V, a Type 1B Topoisomerase with DNA Repair Activities*
TLDR
Topo V has at least two active sites capable of processing AP DNA, and it is demonstrated that Topo78 and Topo34 possess AP lyase activities that are important in base excision DNA repair.
Gadd45a regulates matrix metalloproteinases by suppressing ΔNp63α and β-catenin via p38 MAP kinase and APC complex activation
TLDR
Gadd45a is able to repress ΔNp63α, β-catenin, and consequently MMP expression by two means: by maintaining UVR-induced p38 MAPK and p53 activation and also by associating with the APC complex, which implicates Gadd 45a in the negative regulation of cell migration, and invasion.
A type IB topoisomerase with DNA repair activities
TLDR
Topo V is the prototype for a new subfamily of type IB topoisomersases and is the first example of a topoisomerase with associated DNA repair activities.
Helix–hairpin–helix motifs confer salt resistance and processivity on chimeric DNA polymerases
TLDR
The approach to raise the salt tolerance, processivity, and thermostability of Taq and Pfu DNA polymerases may be applied to all pol1- and polB-type polymerases, as well as to other DNA processing enzymes.
Geographical genotypes (geotypes) of poliovirus case isolates from the former Soviet Union: relatedness to other known poliovirus genotypes.
A 150 nucleotide long region corresponding to adjoining segments of the genes encoding polypeptides VP1 and 2A of 84 poliovirus strains recently isolated from patients with paralytic poliomyelitis
Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A.
TLDR
It is demonstrated that HMGN1, a nuclear protein that binds specifically to nucleosomes, modulates the level of histone H2A phosphorylation, and supports the suggestion that structural chromatin binding proteins can modify the whole profile of post-translational modifications of core histones.
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