• Publications
  • Influence
Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes.
TLDR
While eumelanin was the predominant melanin in these epidermis, phaeomelan in was the major melan in the cultured melanocytes, and these observations may have important implications for the use of cultured human melanocytes in the study of melanogenesis in man. Expand
The expression of functional MSH receptors on cultured human melanocytes
TLDR
The results show that human melanocytes in culture express MSH receptors and that this expression can be modulated by mitogens. Expand
Nle4DPhe7 alpha-melanocyte-stimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes.
TLDR
It is demonstrated that Nle4DPhe7 alpha MSH affects melanin type in human melanocytes and a possible mechanism by which this peptide induces skin darkening in man is suggested. Expand
Cultured human melanocytes respond to MSH peptides and ACTH.
TLDR
It is demonstrated that alpha-MSH and its synthetic analogue Nle4DPhe7 alpha- MSH (NDP-MSh) induce dose-related increases in melanin content and tyrosinase activity and affect cell morphology in the majority of human melanocyte cultures. Expand
Human Melanocytes Express Functional Melanocyte‐Stimulating Hormone Receptors a
The role of laminin in cancer invasion and metastasis.
  • G. Hunt
  • Biology, Medicine
  • Experimental cell biology
  • 1989
TLDR
The role of laminin in tumour invasion and metastasis, and the possible role of the molecule in antimetastasis therapy, is discussed. Expand
Melanocyte-stimulating hormone: a regulator of human melanocyte physiology.
  • G. Hunt
  • Biology, Medicine
  • Pathobiology : journal of immunopathology…
  • 1 July 1995
TLDR
Recent work on the responses of human melanocytes to MSH peptides is reviewed and it is demonstrated that these peptides may be key regulators ofhuman melanocyte physiology. Expand
Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melanogenesis.
  • G. Hunt, A. Thody
  • Biology, Medicine
  • The Journal of endocrinology
  • 1 November 1995
TLDR
It is demonstrated that murine agouti protein causes both a time- and concentration-dependent suppression of melanogenesis in B16 F1 murine melanoma cells, which raises fundamental questions about the mode of action of ag outi protein in regulating melanogenesis. Expand
Alpha-melanocyte stimulating hormone and its analogue Nle4DPhe7 alpha-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes.
TLDR
The preliminary EC50 values for the actions of the MSH peptides suggest that they may be equipotent in their actions on human melanocytes, and it is demonstrated that the common melanocyte mitogens 12-O-tetradecanoyl phorbol-13-acetate (TPA) and cholera toxin affect basal melanogenesis and modulate the effects of theMSH peptide. Expand
ACTH stimulates melanogenesis in cultured human melanocytes.
TLDR
It is suggested that ACTH may be relatively more important than alpha-MSH as a pigmentary hormone in man and could have a physiological role in skin pigmentation. Expand
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