Mechanisms Involved in the Antiplatelet Activity of Staphylococcus aureus Lipoteichoic Acid in Human Platelets
- J. Sheu, Cheng R Lee, M. Yen
- Biology, MedicineThrombosis and Haemostasis
- 1 May 2000
Gram-positive Staphylococcus aureus lipoteichoic acid-mediated alteration of platelet function may contribute to bleeding diathesis in Gram-positive septicemic and endotoxemic patients.
Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP
The main findings of this study suggest that the inhibitory effects of resveratrol possibly involve inhibition of the p38 MAPK‐cytosolic phospholipase A2‐arachidonic acid‐TxA2‐[Ca+2]i cascade and activation of NO/cyclic GMP, resulting in inhibition of phospholIPase C and/or PKC activation.
Antioxidative and hepatoprotective effects of Antrodia camphorata extract.
Results suggest that A. camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities.
Expression of matrix metalloproteinase‐9 in human platelets: regulation of platelet activation in in vitro and in vivo studies
- J. Sheu, Tsorng H. Fong, G. Hsiao
- Biology, ChemistryBritish Journal of Pharmacology
- 1 September 2004
Results strongly indicate that MMP‐9 is a potent inhibitor of aggregation and may play an important role as a negative feedback regulator during platelet activation.
Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats
Results demonstrated that chronic treatment with H4B significantly improved the impaired vascular responses to acetylcholine and suppressed the development of hypertension in SHR but did not affect WKY.
Melatonin prevents endotoxin‐induced circulatory failure in rats
- Chin‐Chen Wu, C. Chiao, G. Hsiao, Ann Chen, M. Yen
- Biology, MedicineJournal of Pineal Research
- 1 April 2001
The pineal secretory product melatonin was found to exert protective effects in septic shock and the results support the clinical use of melatonin in endotoxemia.
Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), in ischemic stroke of rats.
- T. Yen, Chung-King Hsu, J. Sheu
- Biology, MedicineJournal of Agricultural and Food Chemistry
- 29 February 2012
This study demonstrates for the first time that in addition to its originally being considered an agent preventing tumor growth, xanthohumol possesses potent neuroprotective activity, which may represent high therapeutic potential for treatment or prevention of ischemia-reperfusion injury-related disorders.
Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats.
- Jie‐Jen Lee, W. Hsu, J. Sheu
- Biology, MedicineJournal of Ethnopharmacology
- 12 April 2011
Platonin, a photosensitizing dye, improves circulatory failure and mortality in rat models of endotoxemia.
- G. Hsiao, JiJong Lee, J. Sheu
- Biology, MedicineBiological and Pharmaceutical Bulletin
- 1 August 2002
In conclusion, platonin has beneficial effects on ameliorating endotoxaemia, mediated, at least partly, by the reduced drop in MAP and the inhibition of NO and free radical formation in rat models of endotoxemia.
Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets.
- J. Sheu, G. Hsiao, Po-Hsiu Chou, M. Shen, D. Chou
- Biology, ChemistryJournal of Agricultural and Food Chemistry
- 14 July 2004
The results indicate that the antiplatelet activity of rutin may involve the following pathways: r Rutin inhibited the activation of phospholipase C, followed by inhibition of protein kinase C activity and thromboxane A(2) formation, thereby leading to inhibition of the phosphorylation of P47 and intracellular Ca(2+) mobilization, finally resulting in inhibition of platelet aggregation.