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WebLogo: a sequence logo generator.
WebLogo generates sequence logos, graphical representations of the patterns within a multiple sequence alignment. Sequence logos provide a richer and more precise description of sequence similarity… Expand
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first… Expand
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes near promoters, but the locations and roles of histone modifications elsewhere in the genome remain unclear.… Expand
Histone modifications at human enhancers reflect global cell-type-specific gene expression
The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by… Expand
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data… Expand
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine and studies of disease and development. Somatic cell reprogramming involves epigenomic reconfiguration,… Expand
Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to map it at single-base resolution on a genome-wide scale. Affinity purification-based methods cannot… Expand
The ASTRAL Compendium in 2004
- J. Chandonia, G. Hon, +4 authors S. Brenner
- Computer Science, Medicine
- Nucleic Acids Res.
- 15 September 2003
The ASTRAL Compendium provides several databases and tools to aid in the analysis of protein structures, particularly through the use of their sequences. Partially derived from the SCOP database of… Expand
m6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact… Expand
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells.
Human embryonic stem cells (hESCs) share an identical genome with lineage-committed cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse cellular properties in… Expand