Early motor activity drives spindle bursts in the developing somatosensory cortex
- R. Khazipov, A. Sirota, X. Leinekugel, G. Holmes, Y. Ben-Ari, G. Buzsáki
- Biology, PsychologyNature
- 9 December 2004
It is suggested that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination.
Infantile spasms: A U.S. consensus report
- J. Pellock, R. Hrachovy, J. Wheless
- MedicineEpilepsia
- 1 October 2010
The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first‐line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification.
Membrane potential of CA3 hippocampal pyramidal cells during postnatal development.
- R. Tyzio, A. Ivanov, C. Bernard, G. Holmes, Y. Ben‐Ari, R. Khazipov
- BiologyJournal of Neurophysiology
- 1 November 2003
The membrane potential of CA3 pyramidal cells appears to be strongly negative at birth and does not change during postnatal development, and depolarized values of the membrane potential in whole cell and perforated-patch recordings could be explained by a shunt through the seal contact between the pipette and membrane.
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures
- I. Khalilov, G. Holmes, Y. Ben-Ari
- BiologyNature Neuroscience
- 1 October 2003
Data indicate that the excitatory actions of GABA may be a fundamental property of epileptogenic structures, which are capable of generating spontaneous and evoked seizures.
A multicenter study of the efficacy of the ketogenic diet.
- E. Vining, J. Freeman, J. Wheless
- MedicineArchives of Neurology
- 1 November 1998
The ketogenic diet is effective in substantially decreasing difficult-to-control seizures and can successfully be administered in a wide variety of settings.
Excitatory GABA in rodent developing neocortex in vitro.
- S. Rheims, M. Minlebaev, Y. Zilberter
- BiologyJournal of Neurophysiology
- 1 August 2008
A strong GABA excitatory drive coupled with high intrinsic excitability of L5/6 pyramidal neurons and interneurons provide a powerful mechanism of synapse-driven oscillatory activity in the rodent neocortex in vitro.
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures.
- C. Stafstrom, J. Thompson, G. Holmes
- Biology, PsychologyBrain research. Developmental brain research
- 21 February 1992
Role of interictal epileptiform abnormalities in cognitive impairment
- G. Holmes, P. Lenck-Santini
- PsychologyEpilepsy & Behavior
- 1 May 2006
Neurobehavioral and Electroencephalographic Abnormalities in Ube3a Maternal-Deficient Mice
- K. Miura, T. Kishino, J. Wagstaff
- Biology, PsychologyNeurobiology of Disease
- 1 March 2002
A mouse model with targeted inactivation of UBE3a is constructed and maternal-deficient mice show normal brain p53 levels, as predicted from the dependence of Ube3A-mediated ubiquitination of p53 on HPV E6 protein.
Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass.
- D. Bellinger, R. Jonas, R. Strand
- Medicine, PsychologyNew England Journal of Medicine
- 1 July 1995
Heart surgery performed with circulatory arrest as the predominant support strategy is associated with a higher risk of delayed motor development and neurologic abnormalities at the age of one year than is surgery with low-flow bypass as the dominant support strategy.
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