G. Holman

Publications136
h-index46
Citations5,804
Highly Influential Citations138
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Isolation, identification and synthesis of locustamyoinhibiting peptide (LOM-MIP), a novel biologically active neuropeptide from Locusta migratoria
A novel peptide termed locustamyoinhibiting peptide (LOM-MIP) was isolated from brain-corpora cardiaca-corpora allata-suboesophageal ganglion extracts of the locust, Locusta migratoria. The primary… Expand
Aib-Containing Analogues of the Insect Kinin Neuropeptide Family Demonstrate Resistance to an Insect Angiotensin-Converting Enzyme and Potent Diuretic Activity
Analogues of the insect kinin family in which the Xaa2 residue of the C-terminal pentapeptide core sequence Phe-Xaa1-Xaa2-Trp-Gly-NH2 (Xaa1 = Asn, His, Phe, Ser, or Tyr; Xaa2 = Ala, Ser, or Pro) is… Expand
Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin and cholecystokinin.
A sulfated, myotropic neuropeptide termed leucosulfakinin (Glu-Gln-Phe-Glu-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2) was isolated from head extracts of the cockroach Leucophaea maderae. The peptide… Expand
Isolation, primary structure and synthesis of leucomyosuppressin, an insect neuropeptide that inhibits spontaneous contractions of the cockroach hindgut
Abstract 1. A neuropeptide that inhibits spontaneous contractions of the isolated cockroach hindgut was purified from head extracts of the cockroach, Leucophaea maderae . 2. The inability of… Expand
Primary structure and synthesis of a blocked myotropic neuropeptide isolated from the cockroach, Leucophaea maderae.
A peptide which stimulates the contractile activity of the cockroach hindgut was isolated from head extracts of the cockroach, Leucophaea maderae. The inability of aminopeptidase M to degrade the… Expand
The diuretic activity of a series of cephalomyotropic neuropeptides, the achetakinins, on isolated Malpighian tubules of the house cricket, Acheta domesticus
Abstract At 10−9 M achetakinins double the rate of fluid secretion by isolated Malpighian tubules of the house cricket, Acheta domesticus. They appear to act independently of cAMP, and the diuretic… Expand
The concentration-dependence of CRF-like diuretic peptide: mechanisms of action.
The mechanism of action of synthetic CCRF-DP, the corticotropin-releasing factor (CRF)-related diuretic peptide of the salt marsh mosquito Culex salinarius, was investigated in isolated Malpighian… Expand
Leucosulfakinin-II, a blocked sulfated insect neuropeptide with homology to cholecystokinin and gastrin.
A sulfated neuropeptide [pGlu-Ser-Asp-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2], with a blocked N-terminus and related to the undecapeptide leucosulfakinin, has been isolated from head extracts of the… Expand
Isolation, characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica
A competitive ELISA employing a polyclonal antiserum raised against leucokinin-I was used to isolate and purify a myokinin (muscakinin) from 1.05 kg of adult houseflies (Musca domestica). Following… Expand
Locustatachykinin I and II, two novel insect neuropeptides with homology to peptides of the vertebrate tachykinin family
Two myotropic peptides termed locustatachykinin I (Gly‐Pro‐Ser‐Gly‐Phe‐Tyr‐Gly‐Val‐Arg‐NH2) and locustatachykinin II (Ala‐Pro‐Leu‐Ser‐Gly‐Phe‐Tyr‐Gly‐Val‐Arg‐NH2) were isolated from brain‐corpora… Expand
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