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PD 124,895 and PD 124,966, two new antitumor antibiotics.
The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124,895, is an analog of hydroxyelactocinExpand
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Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo.
The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5 microgram/ml) and L1210 murine leukemia cells (IC50, 2.2 micrograms/ml). Acetomycin also hadExpand
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Guanine-7-oxide, a novel antitumor antibiotic.
A new antibiotic, PD 113,876, was isolated from the culture broth of a Streptomyces sp. and was shown by X-ray diffraction analysis to be the N-7 oxide of guanine. This novel antimetabolite is veryExpand
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PD 118,576: a new antitumor macrolide antibiotic.
The isolation and properties of PD 118,576, a new cytotoxic antibiotic obtained from the culture broth of a Streptomyces sp., are described. The structure of this compound was established by spectralExpand
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The structures of the u.v. chromophoric fragments of the antitumour antibiotics, PD 114,759 and PD 115,028
Methanolysis of the new and very potent antitumour antibiotics PD 114,759 and PD 115,028 afforded the 3′-and 4′-N-(2-methoxypropenoyl)4,5-dimethoxyanthranilate esters of methylExpand
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