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Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant.
Assessing the dissolution behavior of orally inhaled drug products (OIDs) has been proposed as an additional in vitro test for the characterization of innovator and generic drug development. A numberExpand
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In Vitro and in Vivo Anti-Inflammatory Activity of the New Glucocorticoid Ciclesonide
The glucocorticoid ciclesonide is the 2′R-epimer of 2′-cyclohexyl-11β-hydroxy-21-isobutyryloxy-16bH-dioxolo[5′,4′:16,17]pregna-1,4-diene-3,20-dione. The active metabolite desisobutyryl-ciclesonideExpand
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Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A.
We investigated the effect of retinoic acid (RA) and herbimycin A (herb-A) on cell growth, cell differentiation, and colony formation of human neuroblastoma cell lines. The neuroblastoma line SK-N-SHExpand
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Soft drugs—10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: Loteprednol etabonate
An improved synthesis of loteprednol etabonate (chloromethyl 17 alpha-ethoxycarbonyloxy-11 beta-hydroxy-3-oxoandrosta-1,4-diene 17 beta-carboxylate) was achieved. The design of the new type ofExpand
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Differentiation of Human Neuroblastoma Cells: Marked Potentiation of Prostaglandin E‐Stimulated Accumulation of Cyclic AMP by Retinoic Acid
Abstract: Neuroblastoma cells in culture contain low levels of cyclic AMP, a second messenger which plays a major role in neuronal maturation. In this study, human neuroblastoma cells, SK‐N‐SH‐SY5Y,Expand
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Affinities of glucocorticoids for glucocorticoid receptors in the human lung
In human lung we found glucocorticoid receptors in similar concentrations and affinities as in other human organs [1]. Following tests for receptor specifity and for the stability of glucocorticoidsExpand
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Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue
The relative binding affinities (RBA) of two locally used glucocorticoids, rimexolone and flunisolide have been measured for the glucocorticoid receptor of human synovial tissue. The non-fluorinatedExpand
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How the Lung Handles Drugs
Bronchial asthma and allergic rhinitis are among the most common diseases of modern society and to an increasing degree a major cause of illness, hospitalization, loss of productivity, and death.Expand
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Biotinylated human beta-endorphins as probes for the opioid receptor.
The reaction of human beta-endorphin and biotinyl N-hydroxysuccinimide with or without spacer arm, afforded a series of products that were separated by high performance liquid chromatography (HPLC).Expand
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