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Interleukin‐12 Antagonist Activity of Mouse Interleukin‐12 p40 Homodimer in Vitro and in Vivo
Mo(p40)2 is a potent IL-12 antagonist that interacts strongly with the beta 1 subunit of the IL-12R to block binding of moIL-12 to the high-affinity mouse IL-12R. Mo(p40)2, alone or in synergy withExpand
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Insulin delivery
Several alternative methods to parenteral insulin delivery are under investigation, ranging from nasal to intrauterine routes of administration. Although these methods are only in early stages ofExpand
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Risperidone: will it significantly change schizophrenia therapy?
If the claims made for Janssen’s novel antipsychotic, risperidone, are realised in clinical practice, 1993 may see the beginning of a new, improved phase of schizophrenia treatment. According toExpand
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New US asthma guidelines stress early, aggressive treatment
The use of aggressive therapy to establish prompt control at the onset of asthma is one of the key recommendations of the latest guidelines from the US National Asthma Education and PreventionExpand
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Whole-cell DTP vaccines make way for new wave of acellular products
Several diphtheria, tetanus and acellular pertussis (DTaP) vaccines have recently been launched, and their use is set to expand as new studies prove their efficacy in infants (≪6 months of age) asExpand
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MIDAS revisited - perhaps atherosclerosis was not to blame
&There appears to be little agreement regarding the interpretation of data from the Multicentre Isradipine/Diuretic Atherosclerosis Study (MIDAS). While the increase in intima-media thickness (IMT)Expand
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Surprise results from ISIS-4 and GISSI-3
A turnaround in cardiovascular medicine is likely to take place in light of the results of 2 major studies. To the surprise of many, magnesium was found to be of no benefit in patients with acuteExpand
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Antidepressant therapy revisited for bulimia nervosa
The advent of the serotonin reuptake inhibitors has renewed interest in the use of antidepressants for treating bulimia nervosa. The first controlled trial to test the efficacy of fluvoxamine in thisExpand
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European peptic ulcer treatment guidelines questioned
The Maastricht Consensus on the treatment of peptic ulcers recommended the use ofHelicobacter pylorieradication therapy in a wide range of patients with this condition, including those takingExpand
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