Author pages are created from data sourced from our academic publisher partnerships and public sources.
Macrophage signaling in HIV-1 infection
The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus does not rely exclusively on the host cell machinery, but also on viral proteins that act as molecular… Expand
Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to… Expand
The macrophage in HIV-1 infection: From activation to deactivation?
Macrophages play a crucial role in innate and adaptative immunity in response to microorganisms and are an important cellular target during HIV-1 infection. Recently, the heterogeneity of the… Expand
LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
- Valentin Le Douce, L. Colin, +6 authors C. Schwartz
- Biology, Medicine
- Nucleic acids research
- 8 November 2011
Microglial cells are the main HIV-1 targets in the central nervous system (CNS) and constitute an important reservoir of latently infected cells. Establishment and persistence of these reservoirs… Expand
Interleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma.
- A. Doyle, G. Herbein, +4 authors S. Gordon
- Medicine, Biology
- European journal of immunology
- 1 June 1994
Interleukin (IL)-13 is a newly described cytokine expressed by activated lymphocytes. We examined the effects of the murine recombinant cytokine on the phenotype and activation status of elicited… Expand
HIV-1 Latency in Monocytes/Macrophages
Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence… Expand
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of… Expand
HIV and inflammation.
- Anne Zelie Decrion, I. Dichamp, A. Varin, G. Herbein
- Medicine, Biology
- Current HIV research
- 30 June 2005
A main feature of HIV infection is the expression of several proinflammatory cytokines. Proinflammatory cytokines expressed as soluble factors or membrane-bound molecules regulate both HIV… Expand
Is HIV infection a TNF receptor signalling-driven disease?
Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both to… Expand
Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor.
The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) is readily detected after human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages in vitro and is present in… Expand