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Inference of Population Structure using Dense Haplotype Data
A novel inference framework that aims to efficiently capture information on population structure provided by patterns of haplotype similarity and an efficient model-based approach to identify discrete populations using this matrix, which offers advantages over PCA and over existing clustering algorithms in terms of speed, number of separable populations, and sensitivity to subtle population structure.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Moderate powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility.
A Genetic Atlas of Human Admixture History
An atlas of worldwide human admixture history, constructed by using genetic data alone and encompassing over 100 events occurring over the past 4000 years, is revealed, revealing admixture to be an almost universal force shaping human populations.
Evidence for substantial fine-scale variation in recombination rates across the human genome
A new statistical method is applied, which overcomes limitations, to infer patterns of fine-scale recombination rate variation in 74 genes, and finds extensive rate variation both within and among genes.
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
The fine-scale genetic structure of the British population
There is significant pre-Roman but post-Mesolithic movement into southeastern England from continental Europe, and it is shown that in non-Saxon parts of the United Kingdom, there exist genetically differentiated subgroups rather than a general ‘Celtic’ population.
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
The genomic and phenotypic diversity of Schizosaccharomyces pombe
The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain, so this analysis represents a rich resource to examine genotype-phenotype relationships in a tractable model.
Inferring Human Colonization History Using a Copying Model
A statistical approach that uses Single Nucleotide Polymorphism (SNP) data to identify sharing of chromosomal segments between populations and uses the pattern of sharing to reconstruct a detailed colonization scenario is introduced.