• Publications
  • Influence
Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine.
Rolipram improves signal transmission in central noradrenergic neurones at a pre- and postsynaptic level, and is thus a novel approach in antidepressant therapy. In order to prove efficacy,Expand
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Neurochemical perspectives to the function of monoamine oxidase
Abstract– Dopamine (DA) is degradated in part by MAO, an intraneuronal and glial enzyme localized at the outer mitochondrial membrane. DA is a good substrate for MAO‐B and selegiline enhancesExpand
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Susceptibility of Brains from Patients with Alzheimer's Disease to Oxygen-Stimulated Lipid Peroxidation and Differential Scanning Calorimetry
The formation of thiobarbituric-acid-reactive substances (TBARS) indicative of oxygen-induced lipid peroxidation in vitro was assayed in the frontal cortex, hippocampus, putamen, basal nucleus of Meyn
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[Treatment of hypotension caused by psychopharmacological drugs (author's transl)].
  • G. Hebenstreit
  • Medicine
  • Wiener medizinische Wochenschrift
  • 28 February 1981
By monitoring the clinical symptoms and several cardiovascular parameters in patients treated with psychopharmacological agents the effect of the peripheric alpha-sympathomimetic drug midodrine wasExpand
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Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease
Biochemical and mitochondrial DNA analyses were performed in post-mortem brain tissue from seven patients with dementia of Alzheimer's type and age- and sex-matched controls. We analysed allExpand
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The Role of Dopamine in the Control of Neurobiological Functions
It is only 30 years since dopamine (DA) was first measured in human brain tissue by Sano [98] (Fig.1). One year later Ehringer and Hornykiewicz [34] demonstrated a striatal DA deficiency inExpand
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Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences
Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleusExpand
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The Role of Brain Dopamine
The Role of Dopamine in the Control of Neurobiological Functions.- Parkinson's Disease.- Morphological Basis for the Pathobiochemistry of the Nigrostriatal Dopamine Systems.- Pathobiochemistry ofExpand
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A double-blind comparative multicentre study of controlled-release remoxipride, immediate-release remoxipride and haloperidol in schizophrenia.
A double-blind multicentre study comparing the efficacy and safety of remoxipride in controlled-release formulation (REM-CR), given once a day, and immediate-release formulation (REM-IR) andExpand
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Biochemical Membrane Constituents and Activities of Alkaline and Acid Phosphatase and Cathepsin in Cortical and Subcortical Brain Areas in Dementia of the Alzheimer Type
Biochemical substrates and activities of three enzymes were determined in cortical and subcortical brain areas from neuropathologically proven cases with dementia of the Alzheimer type (DAT) and age-m
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