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The order Herpesvirales
The taxonomy of herpesviruses has been updated by the International Committee on Taxonomy of Viruses (ICTV), and the names of some nonhuman primate virus species have been changed.
The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.
The sequence (241 087 bp) of chimpanzee cytomegalovirus (CCMV) is determined and compared with published HCMV sequences from the laboratory strains AD169 and Toledo, with the aim of clarifying the gene content of wild-type H CMV.
High-Level Variability in the ORF-K1 Membrane Protein Gene at the Left End of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Defines Four Major Virus Subtypes and Multiple Variants or Clades in…
Overall, it is suggested that rather than being a newly acquired human pathogen, HHV8 is an ancient human virus that is preferentially transmitted in a familial fashion and is difficult to transmit horizontally in the absence of immunosuppression.
Comparison of Genetic Variability at Multiple Loci across the Genomes of the Major Subtypes of Kaposi’s Sarcoma-Associated Herpesvirus Reveals Evidence for Recombination and for Two Distinct Types of…
Overall, the results suggest that an original recombination event with a related primate virus from an unknown source introduced exogenous right-hand side ORF-K15(M) sequences into an ancient M form of HHV8, followed by eventual acquisition into the subtype C lineage of the modern P-form of theHHV8 genome and subsequent additional, more recent transfers by homologous recombination events into several subtype A and B lineages.
Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.
- E. Cheng, J. Nicholas, J. Hardwick
- BiologyProceedings of the National Academy of Sciences…
- 21 January 1997
Overexpression of KSbcl-2 blocked apoptosis as efficiently as B cl-2, Bcl-xL, or another viral BCl-2 homolog encoded by Epstein-Barr virus, BHRF1, implying that BH3 may not be essential for anti-apoptotic function.
A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant
Viral supernatant from JSC-1 was much more efficient at infecting primary human dermal microvascular endothelial cells (DMVECs) with KSHV than supernatants from BC-3 or BCP-1 PEL cell lines.
The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear…
Results confirm the corrected assignment of the coding capacity of the exon 5 region based on amino acid homology with the equivalent IE2 protein from simian CMV (Colburn) and identify two distinct activator domains from IE2, both of which have acidic characteristics.
The Human Cytomegalovirus IE2 and UL112-113 Proteins Accumulate in Viral DNA Replication Compartments That Initiate from the Periphery of Promyelocytic Leukemia Protein-Associated Nuclear Bodies…
Investigation of the initiation of viral DNA replication compartment formation by studying the localization of viral IE proteins, DNA replication proteins, and the PML protein during productive infection shows that IE2 is incorporated together with the core proteins into viralDNA replication compartments that initiate from the periphery of PODs and then grow to fill the space between groups of P ODs.
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6
The presence of a functional IL-6 homologue encoded by HHV-8 may provide a mechanistic model for the hypothesized role of HHV -8 in KS, MCD and BCBL that involves the mitogenic effects of vlL-6 on surrounding cells.