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The order Herpesvirales
TLDR
The taxonomy of herpesviruses has been updated by the International Committee on Taxonomy of Viruses (ICTV), and the names of some nonhuman primate virus species have been changed. Expand
The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.
TLDR
The sequence (241 087 bp) of chimpanzee cytomegalovirus (CCMV) is determined and compared with published HCMV sequences from the laboratory strains AD169 and Toledo, with the aim of clarifying the gene content of wild-type H CMV. Expand
High-Level Variability in the ORF-K1 Membrane Protein Gene at the Left End of the Kaposi’s Sarcoma-Associated Herpesvirus Genome Defines Four Major Virus Subtypes and Multiple Variants or Clades in
TLDR
Overall, it is suggested that rather than being a newly acquired human pathogen, HHV8 is an ancient human virus that is preferentially transmitted in a familial fashion and is difficult to transmit horizontally in the absence of immunosuppression. Expand
Comparison of Genetic Variability at Multiple Loci across the Genomes of the Major Subtypes of Kaposi’s Sarcoma-Associated Herpesvirus Reveals Evidence for Recombination and for Two Distinct Types of
TLDR
Overall, the results suggest that an original recombination event with a related primate virus from an unknown source introduced exogenous right-hand side ORF-K15(M) sequences into an ancient M form of HHV8, followed by eventual acquisition into the subtype C lineage of the modern P-form of theHHV8 genome and subsequent additional, more recent transfers by homologous recombination events into several subtype A and B lineages. Expand
Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
TLDR
The demonstration of sequence-specific binding at multiple loci suggests that EBNA-1 has pleiotropic functions, which may include control of copy number and segregation of the EBV plasmids as well as initiation of replication. Expand
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells
TLDR
Examination of the intranuclear localization pattern of both the IE1 and IE2 proteins in virus-infected and DNA-transfected cells suggests that these two MIE regulatory proteins may represent critical initial events for efficient lytic cycle infection by HCMV. Expand
The Human Cytomegalovirus IE2 and UL112-113 Proteins Accumulate in Viral DNA Replication Compartments That Initiate from the Periphery of Promyelocytic Leukemia Protein-Associated Nuclear Bodies
TLDR
Investigation of the initiation of viral DNA replication compartment formation by studying the localization of viral IE proteins, DNA replication proteins, and the PML protein during productive infection shows that IE2 is incorporated together with the core proteins into viralDNA replication compartments that initiate from the periphery of PODs and then grow to fill the space between groups of P ODs. Expand
A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant
TLDR
Viral supernatant from JSC-1 was much more efficient at infecting primary human dermal microvascular endothelial cells (DMVECs) with KSHV than supernatants from BC-3 or BCP-1 PEL cell lines. Expand
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.
TLDR
Overexpression of KSbcl-2 blocked apoptosis as efficiently as B cl-2, Bcl-xL, or another viral BCl-2 homolog encoded by Epstein-Barr virus, BHRF1, implying that BH3 may not be essential for anti-apoptotic function. Expand
The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear
TLDR
Results confirm the corrected assignment of the coding capacity of the exon 5 region based on amino acid homology with the equivalent IE2 protein from simian CMV (Colburn) and identify two distinct activator domains from IE2, both of which have acidic characteristics. Expand
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