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Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury.
TLDR
It is suggested that peak CSF IL-6 concentrations correlate with improved outcome following TBI, which helps to characterize the inflammatory reaction associated with TBI and may help to develop improved treatment strategies for patients withTBI.
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Restrictive or Liberal Red‐Cell Transfusion for Cardiac Surgery
TLDR
In patients undergoing cardiac surgery who were at moderate‐to‐high risk for death, a restrictive strategy regarding red‐cell transfusion was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new‐onset renal failure with dialysis, with less blood transfused.
View on Wolters Kluwer
Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial
TLDR
Study sites were successful in reversal of desaturation, patient recruitment, randomization, and follow-up in cardiac surgery, supporting the feasibility of conducting a large multicenter RCT.
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Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury
TLDR
The authors were unable to detect significant improvements in mortality with a liberal as compared to restrictive transfusion strategy in critically ill trauma victims with moderate to severe head injury.
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A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery
TLDR
A pilot study was undertaken to determine adherence to proposed strategies for red blood cell transfusion for patients undergoing cardiac surgery and found variability in transfusion practices.
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Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.
TLDR
In conclusion, acute normotensive, normoxemic hemodilution increased the levels of HIF-1alpha protein and mRNA for Hif-1-responsive molecules and nNOS and VEGF protein levels were also increased within the cerebral cortex of anemic rats at clinically relevant hemoglobin concentrations.
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Acute Surgical Anemia Influences the Cardioprotective Effects of &bgr;-Blockade: A Single-center, Propensity-matched Cohort Study
TLDR
Blocked patients do not seem to tolerate surgical anemia when compared with patients who are naive to &bgr;-blockers, and the restricted cubic spline relationship demonstrated that this difference was restricted to those patients in whom the hemoglobin decrease exceeded 35% of the baseline value.
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Successful treatment using recombinant factor VIIa for severe bleeding post cardiopulmonary bypass
TLDR
This case describes the use of rFVIIa for intractable bleeding postcardiovascular surgery in the presence of nearly normal laboratory markers of coagulation.
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Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma.
TLDR
Hemodilutional anemia reduced cerebral Pbr(O(2)) and oxygen extraction and increased cell death following TBI and support the hypothesis that acute anemia accentuated hypoxic cerebral injury after neurotrauma.
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Six‐Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery
TLDR
In patients undergoing cardiac surgery who were at moderate‐to‐high risk for death, a restrictive strategy for red‐cell transfusion was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new‐onset renal failure with dialysis at 6 months after surgery.
View on Wolters Kluwer
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