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Chronic Wound Healing: A Review of Current Management and Treatments
Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can… Expand
Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection.
- L. Martinez, G. Han, +6 authors J. Friedman
- The Journal of investigative dermatology
- 1 October 2009
Staphylococcus aureus (SA) is a leading cause of both superficial and invasive infections in community and hospital settings, frequently resulting in chronic refractory disease. It is imperative that… Expand
Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model.
- L. Martinez, M. R. Mihu, +5 authors J. Nosanchuk
- Biology, Medicine
- The Journal of infectious diseases
- 1 May 2010
Candida species are a major cause of catheter infections. Using a central venous catheter Candida albicans biofilm model, we demonstrated that chitosan, a polymer isolated from crustacean… Expand
The use of chitosan to damage Cryptococcus neoformans biofilms.
The use of indwelling medical devices (e.g. pacemakers, prosthetic joints, catheters, etc) continues to increase, yet these devices are all too often complicated by infections with biofilm-forming… Expand
Nitric Oxide Releasing Nanoparticles Are Therapeutic for Staphylococcus aureus Abscesses in a Murine Model of Infection
- G. Han, L. Martinez, M. R. Mihu, A. Friedman, J. Friedman, J. Nosanchuk
- Biology, Medicine
- PloS one
- 12 November 2009
Staphylococcus aureus (SA) is a leading cause of a diverse spectrum of bacterial diseases, including abscesses. Nitric oxide (NO) is a critical component of the natural host defense against pathogens… Expand
Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition.
Wound healing is a complex process that involves coordinated interactions between diverse immunological and biological systems. Long-term wounds remain a challenging clinical problem, affecting… Expand
The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections
- M. R. Mihu, U. Sandkovsky, G. Han, J. Friedman, J. Nosanchuk, L. Martinez
- 1 March 2010
Acinetobacter baumannii (Ab) is a frequent cause of hospital acquired pneumonia and recently has increased in incidence as the causative agent of severe disease in troops wounded in Afghanistan and… Expand
Autoinflammatory Disorders: A Review and Update on Pathogenesis and Treatment
The autoinflammatory diseases comprise a broad spectrum of disorders characterized by unchecked activation of the innate immune system. Whereas aberrations in adaptive immunity have long been… Expand
Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.
- A. Friedman, G. Han, +4 authors J. Friedman
- Materials Science, Medicine
- Nitric oxide : biology and chemistry
- 1 August 2008
A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner.… Expand
Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide.
- P. Cabrales, G. Han, P. Nacharaju, A. Friedman, J. Friedman
- American journal of physiology. Heart and…
Erythrocyte free hemoglobin (Hb) induces vasoconstriction due to nitric oxide (NO) scavenging, limiting the NO available for vascular smooth muscle. The central objective of this study was to restore… Expand