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Structural and functional features and significance of the physical linkage between ER and mitochondria
- G. Csordás, C. Renken, +6 authors G. Hajnóczky
- Biology, Medicine
- The Journal of cell biology
- 25 September 2006
The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER).… Expand
Decoding of cytosolic calcium oscillations in the mitochondria
Frequency-modulated oscillations of cytosolic Ca2+ ([Ca2+]c) are believed to be important in signal transduction, but it has been difficult to correlate [Ca2+]c oscillations directly with the… Expand
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as… Expand
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase
- Masao Saotome, D. Safiulina, +5 authors G. Hajnóczky
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 30 December 2008
Calcium oscillations suppress mitochondrial movements along the microtubules to support on-demand distribution of mitochondria. To activate this mechanism, Ca2+ targets a yet unidentified cytoplasmic… Expand
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
Enhanced formation of reactive oxygen species (ROS), superoxide (O2 ·−), and hydrogen peroxide (H2O2) may result in either apoptosis or other forms of cell death. Here, we studied the mechanisms… Expand
Control of mitochondrial motility and distribution by the calcium signal
Mitochondria are dynamic organelles in cells. The control of mitochondrial motility by signaling mechanisms and the significance of rapid changes in motility remains elusive. In cardiac myoblasts,… Expand
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface.
The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize… Expand
Spatial and temporal aspects of cellular calcium signaling
- A. P. Thomas, G. J. Bird, G. Hajnóczky, L. D. Robb-Gaspers, J. Putney
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 November 1996
Cytosolic Ca2+ signals are often organized in complex temporal and spatial patterns, even under conditions of sustained stimulation. In this review we discuss the mechanisms and physi‐ological… Expand
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
The mouse mutant mnd2 (motor neuron degeneration 2) exhibits muscle wasting, neurodegeneration, involution of the spleen and thymus, and death by 40 days of age. Degeneration of striatal neurons,… Expand
Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis.
Local Ca(2+) transfer between adjoining domains of the sarcoendoplasmic reticulum (ER/SR) and mitochondria allows ER/SR Ca(2+) release to activate mitochondrial Ca(2+) uptake and to evoke a matrix… Expand