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Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
Development, differentiation and response to environmental stimuli are characterized by sequential changes in cellular state initiated by the de novo binding of regulated transcriptional factors to… Expand
Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome proliferator‐activated receptor γ (PPARγ) and… Expand
Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins
- R. Phair, P. Scaffidi, +7 authors T. Misteli
- Biology, Medicine
- Molecular and Cellular Biology
- 15 July 2004
ABSTRACT Genome structure and gene expression depend on a multitude of chromatin-binding proteins. The binding properties of these proteins to native chromatin in intact cells are largely unknown.… Expand
NSD1 is essential for early post‐implantation development and has a catalytically active SET domain
The nuclear receptor‐binding SET domain‐containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy. To gain insight into the biological… Expand
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.
Steroid receptors bind to site-specific response elements in chromatin and modulate gene expression in a hormone-dependent fashion. With the use of a tandem array of mouse mammary tumor virus… Expand
Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser
One manifestation of fluorescence resonance energy transfer (FRET) is an increase in donor fluorescence after photobleaching the acceptor. Published acceptor‐photobleaching methods for FRET have… Expand
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription
- Diana A. Stavreva, M. Wiench, +7 authors G. Hager
- Biology, Medicine
- Nature Cell Biology
- 1 September 2009
Studies on glucocorticoid receptor (GR) action typically assess gene responses by long-term stimulation with synthetic hormones. As corticosteroids are released from adrenal glands in a circadian and… Expand
Sequence‐specific positioning of nucleosomes over the steroid‐inducible MMTV promoter.
We have investigated chromatin organization over the MMTV LTR, a promoter regulated by steroid hormones. The studies were performed on cell lines containing BPV‐based episomal constructs. Nucleosome… Expand
Early Th1 cell differentiation is marked by a Tfh cell-like transition.
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we showed interleukin-12… Expand
A genome-wide map of CTCF multivalency redefines the CTCF code.
- Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, +15 authors R. Casellas
- Medicine, Biology
- Cell reports
- 30 May 2013
The "CTCF code" hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs). This model, however, is… Expand