G. Hageman

Publications223
h-index60
Citations16,730
Highly Influential Citations833
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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the… Expand
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An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults in the Western world. Although it has been proposed that a threshold event occurs during normal aging… Expand
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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
Age-related macular degeneration (AMD) is the most common form of irreversible blindness in developed countries. Variants in the factor H gene (CFH, also known as HF1), which encodes a major… Expand
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A role for local inflammation in the formation of drusen in the aging eye.
PURPOSE The accumulation of numerous or confluent drusen, especially in the macula, is a significant risk factor for the development of age-related macular degeneration (AMD). Identifying the origin… Expand
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Seven New Loci Associated with Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative… Expand
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Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
Age‐related macular degeneration (AMD), a blinding disorder that compromises central vision, is characterized by the accumulation of extracellular deposits, termed drusen, between the retinal… Expand
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Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Today, the average life expectancy in developed nations is over 80 years and climbing. And yet, the quality of life during those additional years is often significantly diminished by the effects of… Expand
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The role of inflammation in the pathogenesis of age-related macular degeneration.
Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease to study because of the potential role of demographic, environmental, and other systemic… Expand
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Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F.
We have determined the molecular basis for Usher syndrome type 1F (USH1F) in two families segregating for this type of syndromic deafness. By fluorescence in situ hybridization, we placed the human… Expand
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Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstractBackgroundAge-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of… Expand
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