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Biosynthesis of fungal melanins and their importance for human pathogenic fungi.
The ability of both DOPA- and DHN-melanins to quench free radicals is thought to be an important factor in virulence, in several fungi the production of fungal virulence factors, such as melanin, has been linked to a cAMP-dependent signaling pathway. Expand
Horizontal gene transfer and host specificity of beta‐haemolytic streptococci: the role of a putative composite transposon containing scpB and lmb
It is hypothesized that a horizontal gene transfer caused the exchange of scpB and lmb and that the ability of S. pyogenes, S. agalactiae and group C and G streptococcal strains to colonize or infect human hosts is dependent on their presence. Expand
Sequence-Based Identification of Aspergillus, Fusarium, and Mucorales Species in the Clinical Mycology Laboratory: Where Are We and Where Should We Go from Here?
The purpose of an “identification” method in a clinical microbiology laboratory is the ability to provide a specific name or epithet to an organism rapidly and with precision, without the complex experimental research or detailed phylogenetic analyses vital for a taxonomic “classification’ scheme. Expand
Identification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transposition.
The identification of a genetic locus harboring several genes that are essential for the hemolytic function and pigment production of S. agalactiae was led to by targeted mutagenesis with the vector pGh5, complementation studies with pAT28, or analysis of insertion elements in naturally occurring nonhemolytic mutants. Expand
Species Diversity and Polymorphism in the Exophiala spinifera Clade Containing Opportunistic Black Yeast-Like Fungi
ABSTRACT A monophyletic group of black yeast-like fungi containing opportunistic pathogens around Exophiala spinifera is analyzed using sequences of the small-subunit (SSU) and internal transcribedExpand
Isolation and characterization of a unique group of slowly growing mycobacteria: description of Mycobacterium lentiflavum sp. nov.
A distinct group of slowly growing mycobacteria was identified on the basis of growth characteristics, biochemical and lipid profiles, and nucleic acid analyses, and DNA homology studies, suggesting that these organisms are representatives of a novel species. Expand
Coniosporium perforans and C. apollinis, two new rock-inhabiting fungi isolated from marble in the Sanctuary of Delos (Cyclades, Greece)
Phylogenetic analysis suggests that Phaeosclera dematioides is related to the ascomycetous order Dothideales and Monodictys castaneae to the Pleosporales, whereas the three Coniosporium species studied are a sister group to the Herpotrichiellaceae (Chaetothyriales). Expand
High prevalence of the neurotrope Exophiala dermatitidis and related oligotrophic black yeasts in sauna facilities
Summary. The black yeast Exophiala dermatitidis, an agent of fatal brain infections in East Asia, is common in European steam baths. The related fungi Sarcinomyces phaeomuriformis and ExophialaExpand
Fluorescence In Situ Hybridization with Peptide Nucleic Acid Probes for Rapid Identification of Candida albicans Directly from Blood Culture Bottles
It is concluded that this 2.5-h method for the definitive identification of C. albicans directly from yeast-positive blood culture bottles provides important information for optimal antifungal therapy and patient management. Expand
Molecular Cloning and Characterization ofWdPKS1, a Gene Involved in Dihydroxynaphthalene Melanin Biosynthesis and Virulence in Wangiella(Exophiala) dermatitidis
Reconstitution of 1,8-DHN melanin biosynthesis in awdpks1Δ strain reestablished its resistance to killing by neutrophils and its ability to cause fatal mouse infections and studies using a neutrophil killing assay and a mouse acute-infection model confirmed that all wdpks 1Δ strains were less resistant to killing and less virulent, respectively, than their wild-type parent. Expand