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Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive nonmalignant lymphadenopathy, autoimmune phenomena, and expanded populationsExpand
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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung adenocarcinomas, we developed transgenic mice that express murine K-Ras4b(G12D) under the control ofExpand
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Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.
Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism.Expand
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Development of a flexible and specific gene delivery system for production of murine tumor models
To develop models of human cancer we have expressed the avian retroviral receptor, TVA, under a variety of mammalian promoters in transgenic mice, thus rendering mice susceptible to infection withExpand
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Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death.
Administration of anti-TCR/CD3epsilon antibody in vivo or in thymic organ culture results in the apoptotic death of CD4+/CD8+ thymocytes. In contrast, purified thymocytes in suspension culture areExpand
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Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance
A key issue in cancer biology is whether genetic lesions involved in tumor initiation or progression are required for tumor maintenance. This question can be addressed with mouse models thatExpand
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Defective FAS Mediated Apoptosis in a Human Autoimmune Lymphoproliferative Syndrome. • 46
We recently described 5 unrelated children with autoimmune lymphoproliferative syndrome (ALPS) whom had dominant interfering mutations in Fas, a transmembrane protein of the tumor necrosis receptorExpand