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Reduction of the infectivity of scrapie agent as a model for BSE in the manufacturing process of Trasylol.
The Trasylol manufacturing process was investigated with respect to its capacity for the inactivation/removal of infectivity causing bovine spongiform encephalopathy (BSE). Four process steps wereExpand
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Drug-induced residual damage of murine hematopoietic stem cells measured by a new assay.
A recently developed assay for the measurement of residual stem cell damage after gamma-irradiation was tested to see if it could detect residual drug-induced stem cell damage. In this assay, theExpand
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Relationship between number of spleen colonies and 125IdUrd incorporation into spleen and femur.
Graded numbers of bone marrow (BM) cells were injected into fatally irradiated mice. Eight days later the mice were given 3.0 microCi (1 Ci = 3.7 X 10(10) Bq) of 125IdUrd to label proliferating cellsExpand
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Stem cell quality following irradiation: comparison of IUdR uptake in the spleen and number and size of splenic colonies in bone marrow transfused, fatally irradiated mice.
In order to study radiation induced residual injury in hemopoietic stem cells the number and size of spleen colonies were compared to the incorporation of 125I-labeled iododeoxyuridine (125IUdR) inExpand
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Demand-control of proliferative activity in the hemopoietic system of lethally irradiated mice during transfusion-induced regeneration.
The extent of cell proliferation in the hemopoietic system after bone marrow transfusion of fatally irradiated mice depends on the regeneration of proliferative capacity. This may be modified by theExpand
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In vitro effects of epoxide-bearing alepotriates on mouse early hematopoietic progenitor cells and human T-lymphocytes
The epoxide-bearing valepotriates valtrate/isovaltrate and dihydrovaltrate, isolated from Valerianaceae roots and used as common sedative drugs, were investigated for their effects on untransformedExpand
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Hemopoietic regeneration in murine spleen following transfusion of normal and irradiated marrow: different response of granulocyte/macrophage and erythroid precursors.
To investigate cell proliferation in regenerating spleen, bone marrow of normal and gamma-irradiated donor mice (3 weeks after 5 Gy) was transfused into lethally irradiated recipients. In the donorsExpand
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Long‐term Residual Radiation Effect in the Murine Hematopoietic Stem Cell Compartment a
For the measurement of long-term residual radiation effect in the murine hematopoietic system a test system was developed that quantifies the proliferation ability of progeny of spleen repopulatingExpand
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Inhalation of [123I]alpha1-protease inhibitor: toward a new therapeutic concept of alpha1-protease inhibitor deficiency?
UNLABELLED The alpha1-protease inhibitor (alpha1-Pi) is separated from human serum and is therefore extremely expensive. Because only 2%-3% concentrates in the lung after intravenous administration,Expand
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Examination of the biological safety of a drug derived from mammalian organs.
In order to assess the safety of a biological drug, a variety of factors have to be examined and then brought into an overall context considering the specific aspects of each individual product.Expand
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