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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
- A. Wright, Dorilyn A. Forleo, G. Gunawardana, S. Gunasekera, F. Koehn, O. Mcconnell
- 1 July 1990
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determined… Expand
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering.
- D. Stassi, S. Kakavas, +7 authors L. Katz
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 23 June 1998
A previously unknown chemical structure, 6-desmethyl-6-ethylerythromycin A (6-ethylErA), was produced through directed genetic manipulation of the erythromycin (Er)-producing organism… Expand
Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge.
A new cytotoxic acridine alkaloid that exhibited antitumor activity in vivo was isolated from a marine Dercitus species sponge collected at a depth of 160 m in the Bahamas. This violet alkaloid,… Expand
Dercitine, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp
Two new bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus
Dercitin, a New Biologically Active Acridine Alkaloid from a Deep Water Marine Sponge, Dercitus sp.
Characterization of Novel Macrolide Toxins, Mycolactones A and B, from a Human Pathogen, Mycobacterium ulcerans
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
- P. J. McCarthy, T. A. Pitts, G. Gunawardana, M. Kelly-Borges, S. Pomponi
- Biology, Medicine
- Journal of natural products
- 1 November 1992
Meridine , a polycyclic alkaloid derived from the marine sponge Corticium sp., was found to inhibit the growth of Candida albicans and Cryptococcus neoformans. Activity was also observed against… Expand
Pyridoacridine alkaloids from deep-water marine sponges of the family Pachastrellidae: structure revision of dercitin and related compounds and correlation with the kuanoniamines
The single-crystal X-ray diffraction of a novel alkaloid, stellettamine (15), together with long-range 1 H- 13 C coupling constants obtained by inverse detection methods, and metal chelation studies… Expand
New cytotoxic acridine alkaloids from two deep water marine sponges of the family
Abstract Fused ring alkaloids having the pyridol[4,3,2- mn ]acridine skeleton comprise a new class of marine natural products. 1a–h Their biological activity 1e and challenging structure elucidation… Expand