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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determinedExpand
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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering.
A previously unknown chemical structure, 6-desmethyl-6-ethylerythromycin A (6-ethylErA), was produced through directed genetic manipulation of the erythromycin (Er)-producing organismExpand
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Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge.
A new cytotoxic acridine alkaloid that exhibited antitumor activity in vivo was isolated from a marine Dercitus species sponge collected at a depth of 160 m in the Bahamas. This violet alkaloid,Expand
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Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Meridine [1], a polycyclic alkaloid derived from the marine sponge Corticium sp., was found to inhibit the growth of Candida albicans and Cryptococcus neoformans. Activity was also observed againstExpand
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Pyridoacridine alkaloids from deep-water marine sponges of the family Pachastrellidae: structure revision of dercitin and related compounds and correlation with the kuanoniamines
The single-crystal X-ray diffraction of a novel alkaloid, stellettamine (15), together with long-range 1 H- 13 C coupling constants obtained by inverse detection methods, and metal chelation studiesExpand
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New cytotoxic acridine alkaloids from two deep water marine sponges of the family
Abstract Fused ring alkaloids having the pyridol[4,3,2- mn ]acridine skeleton comprise a new class of marine natural products. 1a–h Their biological activity 1e and challenging structure elucidationExpand
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