Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.
A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.
Efficient and Regioselective Synthesis of β-GalNAc/GlcNAc-Lactose by a Bifunctional Transglycosylating β-N-Acetylhexosaminidase from Bifidobacterium bifidum
A microbial β-N-acetylhexosaminidase is described that exhibited strong transglycosylation activity and strict regioselectivity for β- N- acetyl hexosaminyl lactose synthesis and thus provides a powerful synthetic tool to obtain biologically important GalNAcβ1-3Lac and GlcNAc β1-4Lac.
Synthesis and antitumor activities of glucan derivatives
Converting a β-N-acetylhexosaminidase into two trans-β-N-acetylhexosaminidases by domain-targeted mutagenesis
NMR investigation of protein–substrate interaction revealed an invariable mode of the catalytic cavity of D714T, W773R, and WT BbhI, which paved the way for directed evolution by site-saturation mutagenesis of β-N-acetylhexosaminidase.
Design and comprehensive assessment of a biomimetic tri-layer tubular scaffold via biodegradable polymers for vascular tissue engineering applications.
Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates.
- Lizhen Wang, Shaojie Feng, Lian An, G. Gu, Zhongwu Guo
- Chemistry, BiologyJournal of Organic Chemistry
- 29 September 2015
A convergent strategy was developed for the synthesis of LAM oligosaccharides with an α-1,2-linked dimannopyranose cap at the nonreducing end, verifying the potential of the oligosACcharides for vaccine development and other immunological studies.
Hyaluronic acid oligosaccharide-modified collagen nanofibers as vascular tissue-engineered scaffold for promoting endothelial cell proliferation.
Fabrication and Comprehensive Characterization of Biomimetic Extracellular Matrix Electrospun Scaffold for Vascular Tissue Engineering Applications
- W. Jia, Min Li, Lingzhi Kang, G. Gu, Zhongwu Guo, Zonggang Chen
- Materials Science, BiologyJournal of Materials Science
- 1 August 2019
The results indicate that the biomimetic matrix collagen–HA electrospun nanofibrous scaffold could promote PIECs proliferation and may be a better candidate with endothelial potential for the vascular tissue-engineered inner-layer scaffold.