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Zika Virus in Gabon (Central Africa) – 2007: A New Threat from Aedes albopictus?
- G. Grard, M. Caron, +6 authors E. Leroy
- Medicine, Biology
- PLoS neglected tropical diseases
- 1 February 2014
The first direct evidence of human ZIKV infections in Gabon is provided, and its first occurrence in the Asian tiger mosquito, Aedes albopictus is revealed. Expand
Marburg Virus Infection Detected in a Common African Bat
The discovery of Marburg virus in a common species of fruit bat (Rousettus aegyptiacus) in Gabon is reported as shown by finding virus-specific RNA and IgG antibody in individual bats, extending the known range of the virus. Expand
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.
Analysis of coding sequences of all recognized tick-borne flavivirus species suggest a complex relationship between viruses infecting birds and those infecting mammals and ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages. Expand
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads. Expand
A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples.
SURPI is described, a computational pipeline for pathogen identification from complex metagenomic NGS data generated from clinical samples, and use of the pipeline is demonstrated in the analysis of 237 clinical samples comprising more than 1.1 billion sequences. Expand
Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007
- E. Leroy, D. Nkoghe, +8 authors X. de Lamballerie
- Biology, Medicine
- Emerging infectious diseases
- 1 April 2009
An outbreak of febrile illness occurred in Gabon in 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented… Expand
A real-time RT-PCR method for the universal detection and identification of flaviviruses.
- G. Moureau, S. Temmam, J. Gonzalez, R. Charrel, G. Grard, X. de Lamballerie
- Medicine, Biology
- Vector borne and zoonotic diseases
An optimized molecular protocol that combines the convenient real-time polymerase chain reaction (PCR) format with a broad spectrum of flavivirus detection and identification, and is a good candidate for the identification of previously identified flaviviruses in cell culture and the investigation of field samples, is described. Expand
Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa.
- M. Caron, C. Paupy, +6 authors E. Leroy
- Clinical infectious diseases : an official…
- 15 September 2012
Findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus, has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito. Expand
Genomics and evolution of Aedes-borne flaviviruses.
- G. Grard, G. Moureau, R. Charrel, E. Holmes, E. Gould, X. de Lamballerie
- Biology, Medicine
- The Journal of general virology
Viral evolution was found to be associated with the appearance of new biological characteristics; mutations that may modify the envelope protein structure were identified for seven viruses within the YFV group, and an expansion of host-vector range was identified in the two major evolutionary lineages, which in turn may facilitate the emergence of mosquito-borne flaviviruses. Expand
A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa
Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in Mangala village, Democratic Republic of Congo, Africa, and revealed that BASV is highly divergent and shares less than 34% amino acid identity with any other rhabDovirus. Expand