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Clinical Pharmacokinetics of Metformin
The effect of structural variants of OCTs and other cation transporters on the pharmacokinetics of metformin appears small and the subsequent effects on clinical response are limited, however, intersubject differences in the levels of expression of OCT1 and OCT3 in the liver are very large and may contribute more to the variations in the hepatic uptake and clinical effect of metforms. Expand
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
The result is that paracetamol does not suppress the severe inflammation of rheumatoid arthritis and acute gout but does inhibit the lesser inflammation resulting from extraction of teeth and is also active in a variety of inflammatory tests in experimental animals. Expand
Clearance concepts in pharmacokinetics
The kinetics of a drug eliminated by first-order processes in a perfusion-limited isolated perfused organ system are examined and the virtue of using clearance, instead of half-life, as a correlative parameter between these systems is stressed. Expand
Mechanism of Action of Paracetamol
There is considerable evidence that the analgesic effect of paracetamol is central and is due to activation of descending serotonergic pathways, but its primary site of action may still be inhibition of PG synthesis. Expand
Stereoselective disposition of ibuprofen enantiomers in man.
It was found that formation of ester glucuronide conjugates stereoselectively favoured the S(+) enantiomer, and the kinetics of the individual enantiomers were altered by concurrent administration of the respective optical antipode. Expand
Clinical Pharmacokinetics and Pharmacodynamics of Allopurinol and Oxypurinol
Measurement of plasma concentrations of oxypurinol in selected patients, particularly those with renal impairment, may help to decrease the risk of toxicity and improve the hypouricaemic response. Expand
Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin
Impaired renal function and increased plasma levels of oxypur inol and granulysin correlated with the poor prognosis of allopurinol-SCAR, and an early intervention to increase the clearance of plasma oxypURinol may improve the prognosis. Expand
Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers.
Investigation of the relationships between aspirin dose, total and unbound plasma salicylate concentrations and ototoxicity found hearing loss and tinnitus intensity increased progressively with the aspirin dosage and increasing concentrations of total andunbound plasmasalicylates concentrations. Expand
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis
It is suggested that the development of MALA is due to a positive feedback system involving one or more of these factors: vomiting and diarrhoea, acute kidney injury, high doses or excessive accumulation of metformin, and acute disease states leading to tissue hypoxia. Expand
Stereoselective disposition of ibuprofen enantiomers in infants.
This study has examined the stereoselective disposition of the enantiomers of ibuprofen in four healthy male subjects following separate administration of racemic ibuprofen (800 mg) and of eachExpand