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Highly efficient methane biocatalysis revealed in a methanotrophic bacterium.
Methane is an essential component of the global carbon cycle and one of the most powerful greenhouse gases, yet it is also a promising alternative source of carbon for the biological production ofExpand
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Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment
While polyphenolic compounds have many health benefits, the potential development of polyphenols for the prevention/treatment of neurological disorders is largely hindered by their complexity as wellExpand
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Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy
Quantitative NMR-based metabolite profiling is challenged by the deleterious effects of abundant proteins in the intact blood plasma/serum, which underscores the need for alternative approaches.Expand
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Overview of mass spectrometry-based metabolomics: opportunities and challenges.
The field of metabolomics has witnessed an exponential growth in the last decade driven by important applications spanning a wide range of areas in the basic and life sciences and beyond. Expand
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Esophageal Cancer Metabolite Biomarkers Detected by LC-MS and NMR Methods
Background Esophageal adenocarcinoma (EAC) is a rarely curable disease and is rapidly rising worldwide in incidence. Barret's esophagus (BE) and high-grade dysplasia (HGD) are considered major riskExpand
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Early detection of recurrent breast cancer using metabolite profiling.
We report on the development of a monitoring test for recurrent breast cancer, using metabolite-profiling methods. Using a combination of nuclear magnetic resonance (NMR) and two-dimensional gasExpand
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Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer
Breast cancer is a clinically heterogeneous disease, which necessitates a variety of treatments and leads to different outcomes. As an example, only some women will benefit from chemotherapy.Expand
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NMR Spectroscopy for Metabolomics Research
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the three principal analytical techniques used in metabolomics (the other two being gas chromatography coupled toExpand
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15N-cholamine--a smart isotope tag for combining NMR- and MS-based metabolite profiling.
Recently, the enhanced resolution and sensitivity offered by chemoselective isotope tags have enabled new and enhanced methods for detecting hundreds of quantifiable metabolites in biofluids usingExpand
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Single-Step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy
Abstract1H and 13C NMR spectra of intact human bile were assigned using one-dimensional (1H and 13C) and two-dimensional (1H-1H and 1H-13C) experiments. Individual conjugated bile acids—glycocholicExpand
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