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The biotic ligand model: a historical overview.
TLDR
This journal issue includes papers that describe recent advances with regard to the development of the biotic ligand model and represents a distinct milestone in the ongoing evolution of the BLM approach and, more generally, of approaches to performing ecological assessments for metals in aquatic systems. Expand
Isolation and characterization of mitochondria-rich cell types from the gill of freshwater rainbow trout.
TLDR
Transmission electron microscopy analysis of both the PNA(+) and PNA negative (PNA(-)) fraction showed that PNA binds to MR chloride cells while the P NA(-) cell fraction is comprised of MR cells with features characteristic of pavement cells. Expand
Theoretical considerations underlying Na(+) uptake mechanisms in freshwater fishes.
TLDR
This review will focus on the recent molecular advances for Na(+) uptake in freshwater fish and emphasis will be placed on thermodynamic constraints that prevent electroneutral apical NHE function in most freshwater environments. Expand
Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss.
TLDR
A revised model whereby ASIC4 is proposed as one mechanism for Na(+) uptake from dilute freshwater in the gill of rainbow trout is presented, whereby ASIC is found in the apical region of mitochondrion-rich cells. Expand
Chloride Uptake and Base Secretion in Freshwater Fish: A Transepithelial Ion‐Transport Metabolon?
TLDR
A new model for Cl− uptake in FW fish is proposed whereby the combined action of an apical anion exchanger, cytoplasmic carbonic anhydrase, and basolateral V‐type H+‐ATPase creates a local environment high enough to energize Cl − uptake. Expand
The interrelationships between gill chloride cell morphology and ionic uptake in four freshwater teleosts
TLDR
Investigation of the role of the gill chloride cell in transbranchial Na+ and Cl− uptake in four species of freshwater teleost maintained in water of identical ionic composition revealed distinctive chloride cell and pavement cell morphology in each species. Expand
Localization and characterization of phenamil-sensitive Na+ influx in isolated rainbow trout gill epithelial cells
TLDR
Percoll density-gradient separation, combined with peanut lectin agglutinin (PNA) binding and magnetic bead separation, was used to separate dispersed fish gill cells into sub-populations and concluded that high-density α-MR cells function in branchial Na+ uptake in freshwater fish. Expand
Regulation of branchial V-H+-ATPase, Na+/K+-ATPase and NHE2 in response to acid and base infusions in the Pacific spiny dogfish (Squalus acanthias)
TLDR
Pacific spiny dogfish infused intravenously with either HCl or NaHCO3 resulted in a new steady-state acid-base status at ∼0.3 pH units higher than the controls, and it was found that V-H+-ATPase subcellular localization was mainly cytoplasmic in control and HCl-infused fish, while NaH CO3-infusing fish demonstrated a distinctly basolateral staining pattern. Expand
The physiological consequences of exposure to chronic, sublethal waterborne nickel in rainbow trout (Oncorhynchus mykiss): exercise vs resting physiology
TLDR
Low aerobic capacity persisted in fish previously exposed to nickel despite a clean-water exposure period of 38 days and an almost complete depuration of gill Ni, suggesting that extrabranchial mechanisms of chronic Ni toxicity may also be important. Expand
Distinct Na+/K+/2Cl- cotransporter localization in kidneys and gills of two euryhaline species, rainbow trout and killifish
TLDR
Differences in the pattern of Na+/K+/2Cl- cotransporter (NKCC) expression between species suggest that the differential localization of transporters between the two species represents differences in function between these two euryhaline fishes with different life histories and strategies. Expand
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