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Expression of IGF‐I splice variants in young and old human skeletal muscle after high resistance exercise
TLDR
The data in young subjects indicate that the MGF and IGF‐IEa isoforms are differentially regulated in human skeletal muscle, and an attenuated MGF response to high resistance exercise in the older subjects is indicative of age‐related desensitivity to mechanical loading. Expand
Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload
TLDR
The cDNA of a splice variant of IGF that is produced by active muscle that appears to be the factor that controls local tissue repair, maintenance and remodelling is cloned and the discovery of the locally produced IGF‐1 appears to provide the link between the mechanical stimulus and the activation of gene expression. Expand
Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation
TLDR
The physiological function of a recently cloned splice variant of insulin‐like growth factor‐I (IGF‐I; mechano growth factor (MGF) was studied using an in vitro cell model and blocking the IGF‐I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. Expand
Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch
TLDR
To ascertain if IGF-1 is a regulator of local muscle growth, total RNA was extracted from rabbit muscle induced to undergo rapid hypertrophy using active stretch and from control muscles to confirm that alternative splicing of the insulin-like growth factor 1 gene occurs in muscle in response to physical activity. Expand
Characterization of human skeletal muscle fibres according to the myosin heavy chains they express
TLDR
It was shown that the human equivalent to the rat type IIX MyoHC gene is expressed and this observation was taken to suggest that the previously classified IIB muscle fibres in human muscle express a Myosin heavy chain isoform equivalent toThe rat IIX, not the IIB, and would therefore be more accurately classified as IIX fibres. Expand
Expression of insulin growth factor‐1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation
TLDR
It was concluded that the increased expression of this cytoskeletal protein gene is an indication that the production of IGF‐1 may initially be a response to local damage. Expand
Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein.
TLDR
It is hypothesized that Ankrd2 plays an important role in skeletal muscle hypertrophy, and cDNAs corresponding to mRNAs that increase in relative abundance in response to mechanical stretch of mouse skeletal muscles in vivo were identified. Expand
Mechanical signals and IGF‐I gene splicing in vitro in relation to development of skeletal muscle
TLDR
The data indicate the importance of seeking to understand the physiological signals that determine the ratios of splice variants of some growth factor/tissue factor genes in the early stages of development of skeletal muscle. Expand
Expression and Splicing of the Insulin‐Like Growth Factor Gene in Rodent Muscle is Associated with Muscle Satellite (stem) Cell Activation following Local Tissue Damage
TLDR
To gain insight into the cellular mechanisms involved in local tissue repair, the time courses of expression of two IGF‐I splice variants produced in muscle were determined together with marker genes for satellite cell activation following local muscle damage and it was found that the autocrine splice variant mechano growth factor (MGF) was rapidly expressed and then declined within a few days following both types of damage. Expand
Age‐related loss of skeletal muscle function and the inability to express the autocrine form of insulin‐like growth factor‐1 (MGF) in response to mechanical overload
TLDR
The response of insulin‐like growth factor‐1 (IGF‐1) signalling and the capacity of skeletal muscle to adapt to mechanical overload was studied using synergistic muscle ablation and two muscle IGF‐1 splice variants were measured and found to be differentially regulated at the RNA level. Expand
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