Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
The genome sequence of the plant pathogen Xylella fastidiosa
The complete genome sequence of X. fastidiosa clone 9a5c is reported, providing direct evidence of phage-mediated horizontal gene transfer and indicating that the molecular basis for bacterial pathogenicity is both conserved and independent of host.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
Comparative Analyses of the Complete Genome Sequences of Pierce's Disease and Citrus Variegated Chlorosis Strains of Xylella fastidiosa
The genome sequence of X. fastidiosa (Temecula strain) is reported and it is concluded that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies.
Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri…
Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis.
The akuBKU80 Mutant Deficient for Nonhomologous End Joining Is a Powerful Tool for Analyzing Pathogenicity in Aspergillus fumigatus
To increase the frequency of homologous recombination, the KU80 homologue in Aspergillus fumigatus was inactivated and deletion had no influence on pathogenicity in a low-dose murine infection model.
Multiple Resistance Mechanisms among Aspergillus fumigatus Mutants with High-Level Resistance to Itraconazole
The results suggest that overexpression of one or both of these newly identified drug efflux pump genes of A. fumigatus and/or selection of drug target site mutations are linked to high-level itraconazole resistance and are mechanistic considerations for the emergence of clinical resistance to itraconsazole.
Scientific challenges of bioethanol production in Brazil
- H. Amorim, M. L. Lopes, Juliana Velasco de Castro Oliveira, M. Buckeridge, G. Goldman
- Environmental Science, MedicineApplied Microbiology and Biotechnology
- 7 July 2011
This review provides special emphasis on the selection of new yeast strains, genetic breeding, and recombinant DNA technology, as applied to bioethanol production processes, as applications in Brazil.