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Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate
Endonuclease VIII (Nei) of Escherichia coli is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Nei shares with formamidopyrimidine‐DNA glycosylase (Fpg) sequence homology and aExpand
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Structure of Formamidopyrimidine-DNA Glycosylase Covalently Complexed to DNA*
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. The Schiff base intermediate formed during this reaction betweenEscherichia coli FpgExpand
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Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility
Escherichia coli endonuclease VIII (Nei) excises oxidized pyrimidines from DNA. It shares significant sequence homology and similar mechanism with Fpg, a bacterial 8-oxoguanine glycosylase. TheExpand
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Structure-Based Virtual Screening Approach for Discovery of Covalently Bound Ligands
TLDR
We present a fast and effective covalent docking approach suitable for large-scale virtual screening (VS). Expand
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Militarization and gender: The Israeli experience
  • G. Golan
  • Political Science, Sociology
  • 1 September 1997
Abstract The major effect of militarization on the status of women and gender equality derives from the centrality accorded the army in Israeli society. In a society engaged in war or protractedExpand
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Structure determination of the extracellular xylanase from Geobacillus stearothermophilus by selenomethionyl MAD phasing.
Xylanases are hemicellulases that hydrolyze the internal beta-1,4-glycoside bonds of xylan. The extracellular thermostable endo-1,4-beta-xylanase (EC 3.2.1.8; XT6) produced by the thermophilicExpand
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Prevalence of asthma in 13-14 yr-old schoolchildren across Israel.
There is evidence that the incidence and severity of asthma are increasing worldwide, but there are limited data on asthma in Israel. The aim of this study was to investigate the prevalence andExpand
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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly contributes to tumour initiation and progression.Expand
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Coupling of the nucleotide incision and 3'-->5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences.
Aerobic respiration generates reactive oxygen species (ROS) as a by-product of cellular metabolism which can damage DNA. The complex nature of oxidative DNA damage requires actions of several repairExpand
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Effect of dimer dissociation on activity and thermostability of the alpha-glucuronidase from Geobacillus stearothermophilus: dissecting the different oligomeric forms of family 67 glycoside
The oligomeric organization of enzymes plays an important role in many biological processes, such as allosteric regulation, conformational stability and thermal stability. alpha-Glucuronidases areExpand
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