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Oxidative stress, anti‐oxidant therapies and chronic kidney disease
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, limits longevity and increases costs to health‐care systems worldwide. Its increasing incidence… Expand
Patterns of cell death.
- N. Walker, B. Harmon, G. Gobe, J. Kerr
- Chemistry, Medicine
- Methods and achievements in experimental…
Cell death takes two distinct forms, necrosis and apoptosis. Necrosis is a degenerative phenomenon that follows irreversible injury. Apoptosis, in contrast, appears to be an active process requiring… Expand
Biomarkers in chronic kidney disease: a review.
- R. Fassett, S. Venuthurupalli, G. Gobe, J. Coombes, M. Cooper, W. Hoy
- Kidney international
- 2 October 2011
Chronic kidney disease (CKD) is a major public health problem. The classification of CKD by KDOQI and KDIGO and the routine eGFR reporting have resulted in increased identification of CKD. It is… Expand
Molecular cell biology of androgen receptor signalling.
- N. Bennett, R. A. Gardiner, J. Hooper, D. Johnson, G. Gobe
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 June 2010
The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR nuclear translocation, response element binding and recruitment of, or crosstalk with,… Expand
Mitochondria, reactive oxygen species and cadmium toxicity in the kidney.
The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease. One of… Expand
Anatomical methods in cell death.
Publisher Summary This chapter describes methods for studying the morphology of cell death and the criteria used in identifying apoptosis and necrosis. Electron microscopy provides the most reliable… Expand
Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure.
Administration of human recombinant erythropoietin (EPO) at time of acute ischemic renal injury (IRI) inhibits apoptosis, enhances tubular epithelial regeneration, and promotes renal functional… Expand
Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.
- M. Schumer, M. C. Colombel, +6 authors R. Buttyan
- Biology, Medicine
- The American journal of pathology
- 1 April 1992
A multiparametric analysis to demonstrate that even brief periods of arterial clamping can initiate extensive cell loss in a rat kidney through the process of apoptosis during the 48-hour period… Expand
Erythropoietin protects against ischaemic acute renal injury.
- D. Vesey, Catherine W Cheung, B. Pat, Z. Endre, G. Gobe, D. Johnson
- Nephrology, dialysis, transplantation : official…
- 1 February 2004
BACKGROUND Erythropoietin (EPO) has recently been shown to exert important cytoprotective and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity. The aim of the… Expand
Differentiation of oncocytoma from chromophobe renal cell carcinoma (RCC): can novel molecular biomarkers help solve an old problem?
Standard treatment of renal neoplasms remains surgical resection, and nephrectomy for localised renal cell carcinoma (RCC) still has the best chance of cure with excellent long-term results. For… Expand