• Publications
  • Influence
Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature.
TLDR
The current findings present a PK developmental profile that is relevant to environmental toxicants metabolized and cleared by the pathways represented in the current database, and indicates that premature and full-term neonates tend to have 3 to 9 times longer half-life than adults for the drugs included in the database.
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response
TLDR
The effects of 1-h exposures to methyl tertiary-butyl ether at an ambient concentration of 1.7 ppm on healthy adults and their mood and various environmental attributes, including odor, air quality, temperature, are assessed.
Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents
TLDR
The current analysis utilizes data for caffeine and theophylline, closely related xanthines that are both cytochrome P-450 (CYP) 1A2 substrates, in developing PBPK models for neonates and adults, and a stepwise approach for modeling environmental toxicants in children is proposed.
Genetic Polymorphism in Glutathione Transferases (GST): Population Distribution of GSTM1, T1, and P1 Conjugating Activity
TLDR
The estimated variability is sufficiently large to warrant consideration of GST function distributions in assessments involving GST-mediated activation or detoxification of xenobiotics, and Ideally, such assessments would involve physiologically based toxicokinetic (PBTK) modeling to assess population variability in internal dose.
Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity
TLDR
Evidence is too limited to support the development of a population distribution of CYP2E1 enzyme activity based upon genotypes, and health risk assessments may best rely upon data reporting interindividual variability in CYP 2E1 function for input into physiologically based pharmacokinetic (PBPK) models involving CYP1E1 substrates.
Development of a Single‐Meal Fish Consumption Advisory for Methyl Mercury
  • G. Ginsberg, B. Toal
  • Environmental Science
    Risk analysis : an official publication of the…
  • 1 February 2000
TLDR
Model simulations of the single-meal scenario at different fish meHg concentrations found that concentrations of 2.0 ppm or higher can be associated with maternal hair concentrations elevated above the RfD level for days to weeks during gestation, which might be in addition to a baseline meHG body burden from other types of fish consumption.
Quantitative Approach for Incorporating Methylmercury Risks and Omega-3 Fatty Acid Benefits in Developing Species-Specific Fish Consumption Advice
  • G. Ginsberg, B. Toal
  • Environmental Science
    Environmental health perspectives
  • 3 September 2008
TLDR
A framework for risk/benefit analysis is illustrated that can be used to develop categories of consumption advice ranging from “do not eat” to “unlimited,” with the caveat that unlimited may need to be tempered for certain fish because of other contaminants and end points.
A framework for assessing risks to children from exposure to environmental agents.
TLDR
This article presents a conceptual framework for assessing risks to children from environmental exposures, and identifies at each phase the questions and issues of particular importance for characterizing risks to the developing organism.
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