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Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence
The epigenetic code of DNA methylation is interpreted chiefly by methyl cytosine binding domain (MBD) proteins which in turn recruit multiprotein co-repressor complexes. We previously isolated oneExpand
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p66α–MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2–NuRD complex
Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in cell type-specific transcriptionExpand
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DNA methylation.
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC) has generated much interest and considerable controversy during attempts to understand its significance (forExpand
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A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.
Krüppel-like factors (KLFs) have been systematically screened as potential candidates to regulate human gamma-globin gene expression through its CACCC element. Initially, 21 human proteins that haveExpand
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Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice.
The genes of the vertebrate beta-globin locus undergo a switch in expression during erythroid development whereby embryonic/fetal genes of the cluster are sequentially silenced and adult genes areExpand
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Trans‐activation of an upstream early gene promoter of bovine papilloma virus‐1 by a product of the viral E2 gene.
The approximately 1000 nucleotide long upstream regulatory region (URR) of bovine papilloma virus‐1 (BPV‐1) contains a cis element which responds to trans‐activation by a diffusible factor encoded inExpand
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Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells
ABSTRACT Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virusExpand
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Elimination of Transfusions Through Induction of Fetal Hemoglobin Synthesis in Cooley's Anemia a
Pharmacological stimulation of fetal hemoglobin production is of considerable interest as an alternative approach to therapy for Cooley's anemia. While intravenous compounds have been effective inExpand
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Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA*
Background: Although highly homologous to MBD2, the functional role of MBD3 remains in question. Results: MBD3 preferentially localizes to methylated and, to a lesser degree, unmethylated CpGExpand
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Evolutionary conservation of KLF transcription factors and functional conservation of human gamma-globin gene regulation in chicken.
The Krüppel-like factors (KLFs) are a family of Cys2His2 zinc-finger DNA binding proteins with homology to Drosophila Krüppel. KLFs can bind to CACCC elements, which are important in controllingExpand
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