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Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast… Expand
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
- N. Ioannidis, J. Rothstein, +38 authors W. Sieh
- Biology, Medicine
- American journal of human genetics
- 6 October 2016
The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data. Improved methods… Expand
Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians
Objective To assess the cancer risk in children and adolescents following exposure to low dose ionising radiation from diagnostic computed tomography (CT) scans. Design Population based, cohort, data… Expand
Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies
Paul Pharoah and colleagues evaluate the prognostic significance of immunohistochemical subtype classification in more than 10,000 breast cancer cases with early disease, and examine the influence of… Expand
Risk of cancer after use of fertility drugs with in-vitro fertilisation
BACKGROUND We investigated the incidence of invasive cancer of the breast, ovary, and uterus in a cohort of patients who had undergone in-vitro-fertilisation (IVF) treatment and examined whether… Expand
Multiple newly identified loci associated with prostate cancer susceptibility
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To… Expand
Association analysis identifies 65 new breast cancer risk loci
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast… Expand
Glycemic index and dietary fiber and the risk of type 2 diabetes.
OBJECTIVE To examine associations between type 2 diabetes and fiber, glycemic load (GL), dietary glycemic index (GI), and fiber-rich foods. RESEARCH DESIGN AND METHODS This was a prospective study… Expand
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk… Expand
Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid.
- A. Hodge, D. English, +4 authors G. Giles
- Chemistry, Medicine
- The American journal of clinical nutrition
- 1 July 2007
BACKGROUND Dietary fatty acids may be associated with diabetes but are difficult to measure accurately. OBJECTIVE We aimed to investigate the associations of fatty acids in plasma and diet with… Expand