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Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.
TLDR
By combining the rationale of pro- and prebiotics, the concept of synbiotics is proposed to characterize some colonic foods with interesting nutritional properties that make these compounds candidates for classification as health-enhancing functional food ingredients. Expand
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
TLDR
It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases. Expand
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
TLDR
The future use of prebiotics may allow species-level changes in the microbiota, an extrapolation into genera other than the bifidobacteria and lactobacilli, and allow preferential use in disease-prone areas of the body. Expand
Direct Analysis of Genes Encoding 16S rRNA from Complex Communities Reveals Many Novel Molecular Species within the Human Gut
TLDR
The majority of generated rDNA sequences did not correspond to known organisms and clearly derived from hitherto unknown species within this human gut microflora, including Clostridium coccoides and Eubacterium rectale. Expand
Host-Gut Microbiota Metabolic Interactions
TLDR
A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. Expand
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
TLDR
An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics and the appropriate use and scope of the term probiotic. Expand
Prebiotic effects: metabolic and health benefits
TLDR
The present document has been written by a group of both academic and industry experts and aims to validate and expand the original idea of the prebiotic concept, defined as the selective stimulation of growth and/or activity of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host. Expand
Functional food science and gastrointestinal physiology and function.
TLDR
The development of functional foods for the gut is in its infancy and will be successful only if more fundamental research is done on digestive physiology, the gut microflora, immune system and mucosal function. Expand
Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin.
TLDR
Small changes in diet can alter the balance of colonic bacteria towards a potentially healthier microflora, and a 15-g.day-1 dietary addition of oligofructose or inulin led to Bifidobacterium becoming the numerically predominant genus in feces. Expand
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