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The molecular control of corpus luteum formation, function, and regression.
The generation of transgenic, knockout and knockin mice and the development of innovative technologies have revealed a novel role of several molecules in the reprogramming of granulosa cells into luteal cells and in the hormonal and molecular control of the function and demise of the CL.
A Calcium/Calmodulin-dependent Activation of ERK1/2 Mediates JunD Phosphorylation and Induction of nur77 and20α-hsd Genes by Prostaglandin F2α in Ovarian Cells*
It is established that activation of JunD through a calmodulim-dependent activation of ERK1/2 mediates nur77 induction by PGF2α, and it is demonstrated that this molecular mechanism also mediates 20α-hsd induction.
Prostaglandin F2α-induced Expression of 20α-Hydroxysteroid Dehydrogenase Involves the Transcription Factor NUR77*
- C. Stocco, L. Zhong, Y. Sugimoto, A. Ichikawa, L. Lau, G. Gibori
- BiologyThe Journal of Biological Chemistry
- 24 November 2000
It is demonstrated, for the first time, that PGF2α induces in the corpus luteum the expression of the nuclear orphan receptor and transcription factor, NUR77, which in turn leads to the transcriptional stimulation of 20α-HSD, triggering the decrease in serum progesterone essential for parturition.
The different forms of the prolactin receptor in the rat corpus luteum: developmental expression and hormonal regulation in pregnancy.
Investigation of the corpora lutea of pregnancy in the rat found that the corpus luteum of pregnancy expresses both the short and long forms of the PRL-R with the long form being more abundant, and that both A kinase and tyrosine kinase mediated pathways appear to participate in the up-regulatory mechanism involved in PRl-R mRNA expression.
Does the rat corpus luteum express the progesterone receptor gene?
Results indicate that the rat corpus luteum expresses undetectable levels of PR mRNA and protein, which is not attributable to progesterone-induced down-regulation of PR messenger RNA and protein or to a lack of estrogen-induced up- regulation ofPR mRNA in this tissue.
A calcium/calmodulin-dependent activation of ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells.
It is established, using luteinized granulosa cells, that PGF(2alpha) stimulates in vitro nur77 expression in a time- and dose-dependent manner and it is demonstrated that this molecular mechanism also mediates 20alpha-hsd induction.
Cloning and Characterization of an Ovarian-specific Protein That Associates with the Short Form of the Prolactin Receptor*
Evidence is provided for the involvement of a novel protein in PRL signal transduction and suggest that PRAP may contribute to the luteotropic effects of PRL on the corpus luteum during pregnancy.
Sites of androgen and estradiol production in the second half of pregnancy in the rat.
The results indicate that the placentas are a source of androgen in the second half of pregnancy and that the ovaries and fetuses are a site of estradiol production.
Placental-derived regulators and the complex control of luteal cell function.
Apoptosis in decidual tissue regression and reorganization.
During blastocyst implantation, cellular degeneration of decidual tissue spreads from the antimesometrial region to the mesometrial region to accommodate the developing conceptus. To identify the…