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The role of stress in the pathophysiology of the dopaminergic system
It appears that a critical range of DA turnover is necessary for optimal cognitive functioning after stress, in the response of the CNS to ever-changing environmental demands.
Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
It is suggested that dialysate DA reflects the amine released from NA neurons as well, where DA acts not only as NA precursor but also as co-transmitter, and may depend on NA rather than DA innervation and activity.
Increase in meso‐prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
The intravenous administration of the psychoactive constituent of marijuana, Δ9‐tetrahydrocannabinol (Δ9‐THC) (62.5–1000 μg/kg), and the synthetic cannabinoid agonist WIN 55212,2 (WIN) (62.5–500…
The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study.
- L. Ferraro, M. C. Tomasini, G. Gessa, B. W. Bebe, S. Tanganelli, T. Antonelli
- Chemistry, MedicineCerebral cortex
- 1 August 2001
In vivo and in vitro findings suggest an increase in cortical glutamatergic transmission by CB(1) receptors, an effect that may underlie some of the psychoactive and behavioural actions of acute exposure to marijuana.
BEHAVIORAL EFFECTS INDUCED BY INTRACISTERNALLY INJECTED ACTH AND MSH *
- W. Ferrari, G. Gessa, L. Vargiu
- Chemistry, MedicineAnnals of the New York Academy of Sciences
- 1 February 1963
This report deals with the efforts to identify the optimal amino acid sequence that evokes a complex behavioral syndrome and with the preliminary attempts to localize the site of action of these polypeptides.
Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum.
In rat striatum dopamine inhibits adenylate cyclase activity by acting on postsynaptic dopamine receptors with pharmacological properties of D2 type with a rank order of potency which qualitatively correlates with their relative affinity for D2 receptors.
Evidence for dopamine receptors mediating sedation in the mouse brain
- G. Chiara, M. L. Porceddu, L. Vargiu, A. Argiolas, G. Gessa
- Chemistry, MedicineNature
- 1 December 1976
PomorPHINE and L-dopa have a biphasic action on behaviour; in low doses they decrease motor activity, while in higher doses they cause hyper-motility and sterotypy.
SELECTIVE INCREASE OF BRAIN DOPAMINE INDUCED BY γ‐HYDROXYBUTYRATE: STUDY OF THE MECHANISM OF ACTION *
Abstract— γ‐Hydroxybutyrate (γ‐OH) produces a selective accumulation of brain DA not only in normal animals but also in reserpinized animals. This is especially evident after the administration of…
Ethanol prevents the glutamate release induced by N-methyl-d-aspartate in the rat striatum
The present results suggest that ethanol suppresses glutamate release through an inhibition of NMDA glutamate receptors in the rat striatum.
Depolarization inactivation of dopamine neurons: an artifact?
- G. Mereu, V. Lilliu, P. Vargiu, A. Muntoni, M. Diana, G. Gessa
- Chemistry, MedicineThe Journal of neuroscience : the official…
- 1 February 1995
The inhibitory effect of apomorphine on the firing rate of A9 and A10 DA neurons was prevented 3–4 hr after the acute or last injection of chronic haloperidol or (-)-sulpiride, but it was not influenced by either acute or chronic treatment with SCH 23390.