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Hematological findings and complications of COVID‐19
TLDR
COVID‐19 infected patients, whether hospitalized or ambulatory, are at high risk for venous thromboembolism, and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Expand
Heparin-Induced Thrombocytopenia
TLDR
The treatment consists in discontinuing heparin administration and in setting up an alternative treatment for which two drugs are indicated in France: Orgaran and Refludan. Expand
Prevention and treatment of venous thromboembolism--International Consensus Statement.
The aim of this document is to provide a clear and concise account of the evidence regarding efficacy or harm for various methods available to prevent and manage venous thromboembolism (VTE).
Comparative pharmacokinetics of LMWHs.
TLDR
It is demonstrated that LMWHs have a more predictable response, a greater bioavailability, and a longer aXa t1/2 than unfractionated heparin and pharmacokinetic (PK) and pharmacodynamic (PD) profiles. Expand
Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux).
TLDR
Phase II studies show that the efficacy-to-safety ratio of fondaparinux in the treatment of unstable angina or as an adjunct to thrombolysis in acute myocardial infarction is promising and demonstrated that a single anti-Xa agent devoid of antithrombin activity is a potent antithROMbotic drug. Expand
In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban
TLDR
High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. Expand
Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay
TLDR
Thrombogram-Thrombinoscope assay performed in fresh or in frozen-thawed PRP has an acceptable precision, with low inter-assay and intra-assays coefficient of variations. Expand
Patients With Cancer
TLDR
Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low molecular weight heparin in trauma. Expand
In vitro aspirin resistance detected by PFA‐100TM closure time: pivotal role of plasma von Willebrand factor
TLDR
It is demonstrated that in vitro aspirin‐resistance, revealed by PFA‐100TM CT prolongation failure, is correlated to increased plasmatic vWF:RCo levels, reinforcing its particular importance in PFA•100TM cartridges performance. Expand
Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence.
TLDR
The aim of this document is to provide guidelines for investigation and management of patients with thrombophilia in the presence or absence of venous thromboembolism (VTE). Expand
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