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Overexpression of calsequestrin in L6 myoblasts: formation of endoplasmic reticulum subdomains and their evolution into discrete vacuoles where aggregates of the protein are specifically accumulated.
Calsequestrin (CSQ), the major low-affinity Ca(2+)-binding glycoprotein of striated muscle fibers, is concentrated to yield aggregates that occupy the lumen of the terminal cisternae of theExpand
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  • Open Access
Interplay in Vitro Between ACTH, β-Endorphin, and Glucocorticoids in the Modulation of Spontaneous and Lymphokine-Inducible Human Natural Killer (NK) Cell Activity
Release of pro-opiomelanocortin (POMC)-derived peptides and glucocorticoids characterizes the activation of the hypothalamic-pituitary-adrenal (HPA) axis and represents a major adaptive response toExpand
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Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells
Melatonin plays different physiological functions ranging from the regulation of circadian rhythms to tumor inhibition, owing to its antioxidant, immunomodulatory and anti-aging properties. Due toExpand
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  • Open Access
Down‐modulation of Bcl‐2 sensitizes PTEN‐mutated prostate cancer cells to starvation and taxanes
The critical role of PTEN in regulating the PI3K/Akt/mTOR signaling pathway raises the possibility that targeting downstream effectors of the PI3K pathway, such as Bcl‐2, might be an effectiveExpand
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Effect in Vitro of Breast Cyst Fluid on the Spontaneous and Lymphokine‐Inducible Natural Killer Cell Activity of Patients with Gross Cystic Disease of the Breast a
Gross cystic disease (GCD) is thought to represent an advanced form of the fibrocystic breast disease (FCD) complex. Cysts are not considered premalignant lesions. However, several reports indicateExpand
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Inhibition by cortisol of human natural killer (NK) cell activity.
The effects of cortisol on the natural killer (NK) activity of human peripheral blood mononuclear (PBM) cells were studied in vitro using a direct 4-h 51Cr-release assay and K 562 cell line as aExpand
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Cortisol at physiological concentrations and prostaglandin E2 are additive inhibitors of human natural killer cell activity.
The effects of cortisol and prostaglandin E2 on preparations of human peripheral blood mononuclear cells that mediate natural killer cytotoxicity were evaluated. Natural killer cell activity wasExpand
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Involvement of Ca2+-dependent pathways in the inhibition of human natural killer (NK) cell activity by cortisol.
The role of Ca2+ as a second messenger of the glucocorticoid inhibition of human natural killer (NK) cell activity was evaluated using Ca2+ entry blockers (verapamil and its desmethoxy derivativesExpand
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Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells.
The in vitro efficacy of both EGFR inhibitor gefitinib and mTor inhibitor rapamycin, either administrated alone or in different combination schedules, was analysed in four pancreas cancer cell lines.Expand
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Circadian changes in human natural killer-cell activity.
The circadian changes in natural killer (NK) activity of peripheral blood mononuclear cells (PDM) were studied in five clinically healthy, diurnally active, nocturnally resting women. Data onExpand
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