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Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) is Associated with Reduced Disease-free Survival Following Curative Resection of Pancreatic Adenocarcinoma
- G. Garcea, N. Ladwa, C. P. Neal, M. Metcalfe, A. Dennison, D. Berry
- World Journal of Surgery
- 11 February 2011
Preoperative NLR offers important prognostic information regarding disease-free survival following curative resection of pancreatic ductal adenocarcinoma and Kaplan-Meier survival analysis of patients with NLR > 5 demonstrated a disease- free survival of 12 months compared with 52 months for those patients withNLR < 5 (p < 0.001). Expand
Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance.
- H. Doucas, G. Garcea, C. P. Neal, M. Manson, D. Berry
- European journal of cancer
- 1 February 2005
This Review focuses on the changes observed in gastrointestinal cancers, and since in some tumours, levels of components of the Wnt pathway have been found to correlate with clinical stage, their potential use as prognostic indicators is highlighted. Expand
Prediction of Mortality in Acute Pancreatitis: A Systematic Review of the Published Evidence
Despite the proliferation of scoring systems for grading AP, none are ideal for the prediction of mortality, and with the exception of the APACHE II, the other scores and indexes do not have a high degree of sensitivity, specificity and predictive values. Expand
Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases.
The presence of a pre-operative systemic inflammatory response, but not socioeconomic deprivation, independently predicts shortened survival following resection ofclinopathological data for 174 patients who underwent hepatectomy for CLM. Expand
Major resection of hepatic colorectal liver metastases in elderly patients - an aggressive approach is justified.
- C. Mann, C. P. Neal, +4 authors D. Berry
- European journal of surgical oncology : the…
- 1 April 2008
This study confirms that an aggressive surgical policy towards colorectal metastases in elderly patients is associated with low peri-operative morbidity and mortality, as well as good long-term outcomes. Expand
Management of Acute Non-cirrhotic and Non-malignant Portal Vein Thrombosis: A Systematic Review
- T. Hall, G. Garcea, M. Metcalfe, D. Bilku, A. Dennison
- World Journal of Surgery
- 1 September 2011
Early systemic anticoagulation results in a satisfactory rate of recanalization with minimal procedure-associated morbidity and thrombolysis should be used with caution and only considered if the disease is progressive and signs of mesenteric ischemia are present. Expand
Molecular prognostic markers in resectable colorectal liver metastases: a systematic review.
A biomarker-based approach may yield significant benefits through informed treatment of resectable metastatic colorectal malignancy through analysis of multiple molecular markers and the derivation of disease profiles associated with disease recurrence and poor survival. Expand
Imaging of indeterminate pancreatic cystic lesions: a systematic review.
- M. J. Jones, A. Buchanan, C. P. Neal, A. Dennison, M. S. Metcalfe, G. Garcea
- Pancreatology : official journal of the…
- 1 July 2013
CT is a good quality initial investigation to be used in conjunction with clinical data and MRCP can add useful information regarding MPD communication but should be used judiciously. Expand
Nine-Year Single-Center Experience with Nonparastic Liver Cysts: Diagnosis and Management
- G. Garcea, C. Pattenden, J. Stephenson, A. Dennison, D. Berry
- Digestive Diseases and Sciences
It is concluded that laparoscopic liver cyst deroofing is an effective method of dealing with symptomatic nonparasitic liver cysts. Expand
Role of Inflammation in Pancreatic Carcinogenesis and the Implications for Future Therapy
Sustained damage caused by chronic inflammation may precede the onset of frank malignancy by a significant interval and suppression of inflammatory changes and oxidative damage, may help delay or even prevent the inception of pancreatic neoplasia. Expand