• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy
TLDR
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
TLDR
There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere. Expand
A Novel Coronavirus from Patients with Pneumonia in China, 2019
TLDR
Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans. Expand
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
TLDR
The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Expand
A novel coronavirus outbreak of global health concern
TLDR
The detection of infection in at least one household cluster— reported by Jasper Fuk-Woo Chan and colleagues in The Lancet—and the recently documented infections in health-care workers caring for patients with 2019-nCoV indicate human-to-human transmission and thus the risk of much wider spread of the disease. Expand
Human infection with a novel avian-origin influenza A (H7N9) virus.
  • R. Gao, B. Cao, +42 authors Y. Shu
  • Biology, Medicine
  • The New England journal of medicine
  • 15 May 2013
TLDR
Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died. Expand
Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark
TLDR
This is the first comprehensive report documenting the 2006 epidemic of atypical PRRS outbreak in China and identifying the 30 amino-acid deletion in NSP2, a novel determining factor for virulence which may be implicated in the high pathogenicity of PRRSV, and will stimulate further study by using the infectious cDNA clone technique. Expand
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
TLDR
This review aims to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans. Expand
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
TLDR
This series of crystal structures, which is the first, to the authors' knowledge, of any protein from the SARS virus, reveal substantial pH-dependent conformational changes, and an unexpected mode of inhibitor binding, providing a structural basis for rational drug design. Expand
Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010
TLDR
A comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations is done to guide policy responses to the changing disease spectrum in China. Expand
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