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Potent inhibition of human phosphodiesterase-5 by icariin derivatives.
TLDR
4,7-bis(2-hydroxyethyl)icaritin (5), where both sugars in 1 were replaced with hydroxyethyl residues, potently inhibited PDE5A1 with an IC50 very close to that of sildenafil (IC50 75 vs 74 nM). Expand
Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling.
TLDR
Olive oil extract prevented the stimulation of MMP-9 expression and secretion in tumor necrosis factor alpha-treated THP-1 cells, a human monocyte-like cell line, providing further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis. Expand
In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes.
TLDR
Results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. Expand
Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
TLDR
It is confirmed that olive oil phenols reduce human platelet aggregability and the hypothesis that cAMP- and cGMP- phosphodiesterases (PDE) could be one of the targets of the biological effect is verified and verified. Expand
Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation.
TLDR
The results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis. Expand
Antiplasmodial activity of Punica granatum L. fruit rind.
TLDR
The in vitro studies support the use of Pg as antimalarial remedy and the mechanism of action of the antiplasmodial compounds is explored. Expand
High antiplasmodial activity of novel plasmepsins I and II inhibitors.
TLDR
New antiplasmodial compounds acting through distinct mechanisms during both the liver and the blood stages of the parasite life cycle are developed on the basis of the "double-drug" approach. Expand
Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L.
TLDR
Although experimental evidence supporting the use of chamomile for gastrointestinal minor spasms dates back to the fifties, cAMP-PDE inhibition as a likely mechanism underlying the spasmolytic activity is reported for the first time. Expand
Anti-plasmodial activity of Ailanthus excelsa.
The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of PlasmodiumExpand
Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
TLDR
The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria. Expand
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