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Inhibition of food intake in obese subjects by peptide YY3-36.
BACKGROUND The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces foodExpand
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Ghrelin enhances appetite and increases food intake in humans.
Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. GhrelinExpand
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Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
Exendin-4 is a long-acting potent agonist of the glucagon-like peptide 1 (GLP-1) receptor and may be useful in the treatment of type 2 diabetes and obesity. We examined the effects of an intravenousExpand
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Oxyntomodulin suppresses appetite and reduces food intake in humans.
Oxyntomodulin (OXM) is released from the gut postprandially, in proportion to energy intake, and circulating levels of OXM are elevated in several conditions associated with anorexia. CentralExpand
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Pancreatic polypeptide reduces appetite and food intake in humans.
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to ingestion of food. Plasma PP has been shown to be reduced in conditions associated with increased food intakeExpand
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The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been reported to decrease body weight, although the mechanism remains unclear. Here we use inExpand
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Inflammatory disease processes and interactions with nutrition.
Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infectedExpand
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Resistant starch improves insulin sensitivity in metabolic syndrome
Diabet. Med. 27, 391–397 (2010)
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Ghrelin increases food intake in obese as well as lean subjects
OBJECTIVE:To investigate whether effects on food intake are seen in obese subjects receiving exogenous administration of ghrelin.DESIGN:Randomised, double-blind, placebo-controlled study ofExpand
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Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively.
Peptide YY (PYY) and glucagon like peptide (GLP)-1 are cosecreted from intestinal L cells, and plasma levels of both hormones rise after a meal. Peripheral administration of PYY(3-36) and GLP-1(7-36)Expand
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