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High prevalence of undiagnosed airflow limitation in patients with cardiovascular disease.
TLDR
AL is frequent in individuals with CVD, particularly in those with CAD attended in the hospital, is largely underdiagnosed and therefore is highly undertreated.
CDP-choline: pharmacological and clinical review.
TLDR
It has been experimentally proven that CDP-choline increases noradrenaline and dopamine levels in the CNS, and pharmacological characteristics suggest that this drug may be suitable for the treatment of cerebral vascular disease, head trauma of varying severity and cognitive disorders of diverse etiology.
Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial
TLDR
Thiopental appeared to be more effective than pentobarbital in controlling intracranial hypertension refractory to first-tier measures, and these findings should be interpreted with caution because of the imbalance in cranial tomography characteristics and the different dosages employed in the two arms of the study.
Systolic volume index by Doppler echocardiography is an useful marker for stratification and prognostic evaluation in patients with severe aortic stenosis and preserved ejection fraction.
TLDR
Analysis of aortic flow by Doppler echocardiography is useful in risk stratification and therapeutic decision-making in patients with aorta stenosis.
Pharmacokinetics and tolerability of a new low molecular mass heparin (RO-11) in healthy volunteers--a dose-finding study within the therapeutical range.
TLDR
The study focused on pharmacokinetics, dose-effect relationship and on tolerability of three single subcutaneous doses within the therapeutical range of RO-11, and found the compound was tolerated very well and no clinically relevant prolongation of APTT, prothrombin and thrombin clotting tests was observed.
Treatment of chronic diabetic foot ulcers with bemiparin: a randomized, triple‐blind, placebo‐controlled, clinical trial
TLDR
The objective is to assess the efficacy and safety of bemiparin in the treatment of chronic diabetic foot ulcers and to establish a protocol to evaluate its use in clinical practice.
Low-dose steroid therapy does not affect hemodynamic response in septic shock patients.
TLDR
Treatment with low-dose steroid therapy was not associated to a reduction in time to shock reversal or mortality in septic shock and neither showed differences between steroid and control group in the inhospital mortality.
Levels of caspase-1 in cerebrospinal fluid of patients with traumatic brain injury: correlation with intracranial pressure and outcome.
TLDR
In this cohort of patients with TBI who were admitted to the neurosurgical ICU, the inflammasome protein caspase-1 is increased in the CSF of patientsWith high ICP, especially on days 2 and 3 after TBI.
Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis
TLDR
A high prevalence of crystallization risk in urine is observed, especially in children with a family history of the disease, and low urinary volume was the factor most associated with increased risk.
Anticalculus effect of a triclosan mouthwash containing phytate: a double-blind, randomized, three-period crossover trial.
TLDR
The high efficacy of phytate in reducing dental calculus formation suggests that this substance may be an effective treatment for preventing the development of calculus deposits.
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