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Benchmarking safety pharmacology regulatory packages and best practice.
- Silvana Lindgren, A. Bass, +6 authors M. Pugsley
- Journal of pharmacological and toxicological…
- 1 September 2008
INTRODUCTION The objectives of this survey were to obtain a global information update regarding current industry perspectives that describe Safety Pharmacology programs as they relate to the ICH S7A… Expand
The complement system in myocardial ischaemia/reperfusion injury.
Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart.
- G. Friedrichs, K. Kilgore, P. Manley, M. Gralinski, B. Lucchesi
- Circulation research
- 1 October 1994
Evidence is presented that heparin pretreatment produces protective effects on myocardial tissue distinct from its anticoagulant activity. The present study examines the ability of heparin sulfate… Expand
Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury.
- S. Black, M. Gralinski, G. Friedrichs, K. Kilgore, E. Driscoll, B. Lucchesi
- Cardiovascular research
- 1 May 1995
OBJECTIVE The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the… Expand
Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis.
BACKGROUND Thrombolytic agents used clinically rely on the activation of plasminogen to plasmin. Plasmin possesses multiple actions including increasing thrombin activity and activation of platelets.… Expand
Protective effects of the SOD-mimetic SC-52608 against ischemia/reperfusion damage in the rabbit isolated heart.
- K. Kilgore, G. Friedrichs, +5 authors B. Lucchesi
- Journal of molecular and cellular cardiology
- 1 August 1994
An experimental model of myocardial ischemia/reperfusion injury was used to assess the cardioprotective effects of SC-52608, a low molecular weight superoxide dismutase mimetic. Langendorff perfused… Expand
Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia
- G. Friedrichs, R. Swillo, +5 authors Kurex Sidek
- Journal of cardiovascular pharmacology
- 1 January 2002
Contractility studies in isolated feline myocytes have demonstrated that sphingosine, a metabolite stimulated by tumor necrosis factor (TNF) binding, decreases intracellular calcium release and… Expand
Effects of tedisamil (KC‐8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart
1 The direct cardiac electrophysiological and antifibrillatory actions of tedisamil (KC‐8857) were studied in rabbit isolated hearts. 2 Tedisamil (1, 3, and 10 μm), prolonged the ventricular… Expand
Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.
INTRODUCTION The propensity of drugs to cause a potentially fatal arrhythmia, torsades des pointes (TdP), is a significant public health issue. The draft International Conference on Harmonization… Expand
Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart
- M. Gralinski, L. Chi, +4 authors B. Lucchesi
- Journal of cardiovascular pharmacology and…
- 1 April 1996
Background: The authors studied the antifibrillatory effects of the adenosine-triphosphate (ATP)-sparing metabolic modulator ranolazine in a rabbit isolated heart model in which ventricular… Expand