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Benchmarking safety pharmacology regulatory packages and best practice.
TLDR
ICH S7A core battery studies are implemented by most of the responding companies with a clear trend of an enhanced submission of renal and GI studies and a diversity of approaches for conducting abuse liability studies, which primarily use the methods of self-administration and drug discrimination.
Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart.
TLDR
Heparin or N-acetyl heparin, administered to the intact rabbit, protects the isolated heart from subsequent myocardial dysfunction secondary to ischemia/reperfusion and is independent of an antithrombin mechanism.
Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury.
TLDR
The glycosaminoglycans, heparin or N-acetylheparin, can reduce the extent of myocardial injury associated with regional ischaemia and reperfusion in the canine heart.
Protective effects of the SOD-mimetic SC-52608 against ischemia/reperfusion damage in the rabbit isolated heart.
TLDR
The hemodynamic, biochemical, morphological, as well as the antimyosin binding data, demonstrate that pretreatment with SC-52608 protects the myocardium from damage associated with global ischemia and reperfusion.
Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia
TLDR
The in vivo study suggests that reducing sphingosine production with N-oleoylethanolamine attenuates cardiodepression and can improve overall survival after ischemic injury and may provide a therapeutic benefit in clinical conditions of myocardial inflammatory injury.
Effects of tedisamil (KC‐8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart
TLDR
The results demonstrate a direct antifibrillatory action of tedisamil in vitro, and the mechanism responsible for the observed effects may involve modulation by ted isamil of the cardiac ATP‐regulated potassium channel, in addition to its antagonism of IK and Ito.
Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis.
TLDR
It is demonstrated that local administration of fibrolase lyses a carotid arterial thrombus rapidly without excessive hemorrhage or hemodynamic compromise and may prove useful as a clinically efficacious alternative to presently used thrombolytic agents.
Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.
TLDR
The survey results indicate that pharmaceutical companies are testing for VR prolongation of drug candidates and that institutions have established in-house or outsourced capabilities to evaluate this potential risk, even in the absence of final guidelines.
Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart
TLDR
Ranolazine significantly reduced the incidence of ventricular fibrillation in the hypoxic/reoxygenated heart exposed to the ATP-dependent potassium channel opener, pinacidil.
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