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Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
TLDR
MDR tuberculosis is more prevalent than previously realised in a rural area in KwaZulu Natal, South Africa and has been transmitted to HIV co-infected patients and is associated with high mortality. Expand
Timing of initiation of antiretroviral drugs during tuberculosis therapy.
TLDR
The initiation of antiretroviral therapy during tuberculosis therapy significantly improved survival and provides further impetus for the integration of tuberculosis and HIV services. Expand
A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection.
TLDR
The data suggest that in HIV-infected persons tuberculosis most often results from the reactivation of latent tuberculous infection; these results lend support to recommendations for the aggressive use of chemoprophylaxis against tuberculosis in patients with HIV infection and a positive PPD test. Expand
Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence
TLDR
In this analysis, ART adherence was associated with improved QoL, particularly if adherence was sustained, and those with at least 80% ART adherence had smaller gains inQoL at 12 months when compared to baseline, while those with <80% adherence had worsening of QoG. Expand
Integration of antiretroviral therapy with tuberculosis treatment.
TLDR
Deferral of the initiation of ART to the first 4 weeks of the continuation phase of tuberculosis therapy in those with higher CD4+ T-cell counts reduced the risks of IRIS and other adverse events related to ART without increasing the risk of AIDS or death. Expand
Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs
TLDR
Multifaceted, interdisciplinary approaches are urgently needed to achieve parity in health outcomes in HIV-infected drug users. Expand
Infective endocarditis: an analysis based on strict case definitions.
TLDR
Patients in this study had an advanced mean age, high incidence of underlying valvular disease, short mean duration of symptoms, and 15% mortality, the lowest reported for a large series. Expand
The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials.
TLDR
Long-term antiretroviral adherence patterns and their impact on biologic outcomes for human immunodeficiency virus (HIV)-infected participants in 2 randomized, multicenter clinical trials were prospectively studied. Expand
Trust and the Acceptance of and Adherence to Antiretroviral Therapy
TLDR
Characteristics of the therapeutic agents and the degree of social isolation predict adherence, which may inform the design of interventions to improve both acceptance of and adherence to ART particularly among marginalized populations who have not derived full benefit from these potent new therapies. Expand
Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome.
TLDR
In patients at high risk for AIDS, the presence of unexplained oral candidiasis predicts the development of serious opportunistic infections more than 50 per cent of the time. Expand
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