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Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
The efflux pumps ABCB1 (p-gp, MDR1) and ABCG2 (BCRP) are expressed to a high extent by endothelial cells at the blood-brain barrier (BBB) and other barrier tissues and are involved in drug resistanceExpand
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Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats
Intestinal ATP binding cassette (ABC) transporters may affect the bioavailability and effectiveness of orally administered drugs. Available studies on regional expression of intestinal effluxExpand
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  • Open Access
Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells
Confocal laser scanning microscopy (CLSM) was used to quantify and visualize the transport of the octapeptide and somatostatin analogue, octreotide (SMS 201-995, Sandostatin), across monolayers ofExpand
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Compound Profiling for P-Glycoprotein at the Blood–Brain Barrier Using a Microplate Screening System
AbstractPurpose. The purpose of this study was to establish a fluorescent dye (calcein-acetoxymethylester; calcein-AM)-based assay to rapidly screen compounds for interactions with p-glycoproteinExpand
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  • Open Access
Heart failure due to enlarged tonsils and adenoids. The cardiorespiratory syndrome of increased airway resistance.
COR PULMONALE is a rare disease in the pediatric age group 1 but its recognition is very important since emergency therapy is often essential for survival, and many cases are completely reversibleExpand
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Inhibition of P-glycoprotein by two artemisinin derivatives
P-Glycoprotein/MDR1 represents an important component of the blood brain barrier and contributes to multidrug resistance. We investigated two derivatives of the anti-malarial artemisinin, SM616 andExpand
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  • Open Access
Syddansk Universitet Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
Drug permeability of the model drugs ketoprofen and nadolol across Caco-2 cell monolayers was determined in the absence and presence of the non-ionic surfactant Poloxamer 188 (Pluronic F68, P-188).Expand
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  • Open Access
Overcoming MDR at the blood–brain barrier
Abstract The brain capillaries represent at major barrier preventing entry into the brain for xenobiotics and many drugs, which otherwise may be therapeutically active in the central nervous system.Expand
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Frequency of urinary tract abnormalities in sickle cell disease.