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Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs.
Resolution of acute inflammation is an active process that involves the biosynthesis of specialized proresolving lipid mediators. Among them, resolvin D1 (RvD1) actions are mediated by two GExpand
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Infection Regulates Pro-Resolving Mediators that Lower Antibiotic Requirements
Underlying mechanisms for how bacterial infections contribute to active resolution of acute inflammation are unknown. Here, we performed exudate leukocyte trafficking and mediator-metabololipidomicsExpand
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Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury1
Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. We report that,Expand
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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway
Significance Specialized proresolving mediators, such as resolvin D1 (RvD1), are endogenous molecules that both dampen inflammation without compromising host defense and promote tissue resolution. AExpand
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Inflammation and its Resolution as Determinants of Acute Coronary Syndromes
Inflammation contributes to many of the characteristics of plaques implicated in the pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only regulate the properties ofExpand
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Resolvin E2 Formation and Impact in Inflammation Resolution
Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. In this context, specialized proresolving mediators derived from polyunsaturated fatty acids areExpand
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Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
During the resolution phase of inflammation, the 'corpses' of apoptotic leukocytes are gradually cleared by macrophages. Here we report that during the resolution of peritonitis, the CCR5 chemokineExpand
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The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering*
Docosahexaenoic acid, a major ω-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases byExpand
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Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets.
Resolvin E1 (RvE1) is an omega-3 eicosapentaenoic acid (EPA)-derived lipid mediator generated during resolution of inflammation and in human vasculature via leukocyte-endothelial cell interactions.Expand
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MicroRNAs in resolution of acute inflammation: identification of novel resolvin Dl‐miRNA circuits
Mechanisms controlling resolution of acute inflammation are of wide interest. Here, we investigated microRNAs (miRNAs) in self‐limited acute inflammatory exudates and their regulation by resolvin D1Expand
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